E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset

Viacheslav Yu. Pauls.

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  • Abstract
    The purpose of this paper is to study the redox status and biochemical parameters of T341P desminopathy in a heterozygous state. Most
    of the studied indicators of oxidative stress increase when approaching the middle course of T341P desminopathy. In particular, malondialdehyde and 8-OH-deoxyguanosine increase by 1.2 and 2 times, respectively, and the content of glutathione and coenzyme Q10 increase
    by 1.9 times. An increase in the level of uric acid in the blood of the proband was established up to 1.5 times, exceeding the upper reference
    limits by 10 - 12%. With the progression of desminopathy, decreased functional activity of the kidneys occurs with a considerable reduction
    in glomerular filtration. Five days before the death of the probandÂ’s father suffering from desminopathy, serious changes were observed in
    nitrogen metabolism. The data obtained complements the picture of pathological mechanisms impacting desminopathy.

    Key words: Desminopathy, Myoglobin, Nitrogen metabolism, Redox status, Uric acid.


     
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    Pubmed Style

    Viacheslav Yu. Pauls. Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset. PNR. 2021; 12(2): 24-28. doi:10.47750/pnr.2021.12.02.004


    Web Style

    Viacheslav Yu. Pauls. Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset. https://www.pnrjournal.com/?mno=116535 [Access: August 12, 2022]. doi:10.47750/pnr.2021.12.02.004


    AMA (American Medical Association) Style

    Viacheslav Yu. Pauls. Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset. PNR. 2021; 12(2): 24-28. doi:10.47750/pnr.2021.12.02.004



    Vancouver/ICMJE Style

    Viacheslav Yu. Pauls. Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset. PNR. (2021), [cited August 12, 2022]; 12(2): 24-28. doi:10.47750/pnr.2021.12.02.004



    Harvard Style

    Viacheslav Yu. Pauls (2021) Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset. PNR, 12 (2), 24-28. doi:10.47750/pnr.2021.12.02.004



    Turabian Style

    Viacheslav Yu. Pauls. 2021. Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset. Journal of Pharmaceutical Negative Results, 12 (2), 24-28. doi:10.47750/pnr.2021.12.02.004



    Chicago Style

    Viacheslav Yu. Pauls. "Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset." Journal of Pharmaceutical Negative Results 12 (2021), 24-28. doi:10.47750/pnr.2021.12.02.004



    MLA (The Modern Language Association) Style

    Viacheslav Yu. Pauls. "Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset." Journal of Pharmaceutical Negative Results 12.2 (2021), 24-28. Print. doi:10.47750/pnr.2021.12.02.004



    APA (American Psychological Association) Style

    Viacheslav Yu. Pauls (2021) Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset. Journal of Pharmaceutical Negative Results, 12 (2), 24-28. doi:10.47750/pnr.2021.12.02.004