E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda.

Abstract
Objective: To systematically examine the prognostic significance of isocitrate dehydrogenase 1 (IDH1) mutations according to country region. Methods: We searched five electronic databases from inception to September 2019 for relevant studies. A meta-analysis was performed after evaluating which studies met the inclusion criteria. Thirty-seven were identified for this meta-analysis, comprising 5141 GBM patients. Results: The benefit of overall survival (OS) was the hazard ratio (HR), 0.67 (95% confidence interval [CI], 0.610.74). When subgroup analysis by country region, the pooled HR for the Eastern population studies was 1.15 (95% CI: 0.971.35) with no association between IDH1 mutation and OS of GBM, while IDH1 mutation still had a significant survival advantage in the Western population studies (HR: 0.51, 95% CI: 0.450.57). Conclusions: This study confirmed that IDH1 mutation is an independent prognostic factor for patients with GBM. However, a topographic relationship was observed in the results, and an association between this genetic mutation and prognosis should be explored in future studies.

Key words: Glioblastoma, isocitrate dehydrogenase 1, meta-analysis, survival, systematic review


 
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How to Cite this Article
Pubmed Style

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda. No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis. pnr. 2020; 11(1): 1-8. doi:10.4103/jpnr.JPNR_22_19


Web Style

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda. No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis. http://www.pnrjournal.com/?mno=133346 [Access: September 22, 2020]. doi:10.4103/jpnr.JPNR_22_19


AMA (American Medical Association) Style

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda. No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis. pnr. 2020; 11(1): 1-8. doi:10.4103/jpnr.JPNR_22_19



Vancouver/ICMJE Style

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda. No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis. pnr. (2020), [cited September 22, 2020]; 11(1): 1-8. doi:10.4103/jpnr.JPNR_22_19



Harvard Style

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda (2020) No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis. pnr, 11 (1), 1-8. doi:10.4103/jpnr.JPNR_22_19



Turabian Style

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda. 2020. No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis. Journal of Pharmaceutical Negative Results, 11 (1), 1-8. doi:10.4103/jpnr.JPNR_22_19



Chicago Style

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda. "No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis." Journal of Pharmaceutical Negative Results 11 (2020), 1-8. doi:10.4103/jpnr.JPNR_22_19



MLA (The Modern Language Association) Style

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda. "No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis." Journal of Pharmaceutical Negative Results 11.1 (2020), 1-8. Print. doi:10.4103/jpnr.JPNR_22_19



APA (American Psychological Association) Style

Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda (2020) No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis. Journal of Pharmaceutical Negative Results, 11 (1), 1-8. doi:10.4103/jpnr.JPNR_22_19