E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


Insignificant antidiabetic activities of ethanolic extracts of seeds of Archidendron pauciflorum

Sundarasekar Jeevandran, Sahgal Geethaa, Wong Jin Yi, See Wei Yuan, Subramani Parasuraman, Sundram Karupiah.

Abstract
Background: Archidendron pauciflorum (Fabaceae), commonly recognised as Dogfruit or Jering (Malaysia), is indigenous to Southeast Asia. The pounded leaves and bark of A. pauciflorum are used to treat gum pains, toothache, chest pains, skin ailments, and wounds. The antidiabetic effect of A. pauciflorum is not clear; hence, the present study is planned to evaluate the antidiabetic activities of ethanol extract of seeds of A. pauciflorum (ESAP) using both in vitro and in vivo models. Materials and Methods: Seeds of A. pauciflorum were sequentially extracted with hexane, chloroform, and ethanol, and the ethanolic extract was used in this study due to its various phytochemical constituents. Inhibitory activity of α-amylase and α-glucosidase (in vitro) was measured using the spectrophotometric method. For in vivo study, rats were used to induce diabetes mellitus (induced by streptozotocin) and ESAP was administered at the dose levels of 125, 250, and 500 mg/kg once daily through oral gavage for 21 consecutive days, and the antidiabetic effect of ESAP was compared with glibenclamide. Changes in glucose level and body weight were measured at regular intervals. Results: In vitro inhibition studies demonstrated that the ESAP had a moderate inhibitory activity for α-amylase and α-glucosidase. The rats treated with ESAP showed a significant decrease in their body weight at 21 days, whereas the glibenclamide treated rats showed a significant increase in their body weight. The standard drug glibenclamide was observed to significantly lower the blood glucose level, whereas the extract treated group did not show a significant change in levels of blood glucose when compared with control. Conclusion: The ESAP did not show any antidiabetic effect on diabetic rats.

Key words: Glibenclamide, glucose, streptozotocin, α-amylase, α-glucosidase


 
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How to Cite this Article
Pubmed Style

Sundarasekar Jeevandran, Sahgal Geethaa, Wong Jin Yi, See Wei Yuan, Subramani Parasuraman, Sundram Karupiah. Insignificant antidiabetic activities of ethanolic extracts of seeds of Archidendron pauciflorum. pnr. 2020; 11(1): 47-53. doi:10.4103/jpnr.JPNR_10_20


Web Style

Sundarasekar Jeevandran, Sahgal Geethaa, Wong Jin Yi, See Wei Yuan, Subramani Parasuraman, Sundram Karupiah. Insignificant antidiabetic activities of ethanolic extracts of seeds of Archidendron pauciflorum. http://www.pnrjournal.com/?mno=133394 [Access: September 22, 2020]. doi:10.4103/jpnr.JPNR_10_20


AMA (American Medical Association) Style

Sundarasekar Jeevandran, Sahgal Geethaa, Wong Jin Yi, See Wei Yuan, Subramani Parasuraman, Sundram Karupiah. Insignificant antidiabetic activities of ethanolic extracts of seeds of Archidendron pauciflorum. pnr. 2020; 11(1): 47-53. doi:10.4103/jpnr.JPNR_10_20



Vancouver/ICMJE Style

Sundarasekar Jeevandran, Sahgal Geethaa, Wong Jin Yi, See Wei Yuan, Subramani Parasuraman, Sundram Karupiah. Insignificant antidiabetic activities of ethanolic extracts of seeds of Archidendron pauciflorum. pnr. (2020), [cited September 22, 2020]; 11(1): 47-53. doi:10.4103/jpnr.JPNR_10_20



Harvard Style

Sundarasekar Jeevandran, Sahgal Geethaa, Wong Jin Yi, See Wei Yuan, Subramani Parasuraman, Sundram Karupiah (2020) Insignificant antidiabetic activities of ethanolic extracts of seeds of Archidendron pauciflorum. pnr, 11 (1), 47-53. doi:10.4103/jpnr.JPNR_10_20



Turabian Style

Sundarasekar Jeevandran, Sahgal Geethaa, Wong Jin Yi, See Wei Yuan, Subramani Parasuraman, Sundram Karupiah. 2020. Insignificant antidiabetic activities of ethanolic extracts of seeds of Archidendron pauciflorum. Journal of Pharmaceutical Negative Results, 11 (1), 47-53. doi:10.4103/jpnr.JPNR_10_20



Chicago Style

Sundarasekar Jeevandran, Sahgal Geethaa, Wong Jin Yi, See Wei Yuan, Subramani Parasuraman, Sundram Karupiah. "Insignificant antidiabetic activities of ethanolic extracts of seeds of Archidendron pauciflorum." Journal of Pharmaceutical Negative Results 11 (2020), 47-53. doi:10.4103/jpnr.JPNR_10_20



MLA (The Modern Language Association) Style

Sundarasekar Jeevandran, Sahgal Geethaa, Wong Jin Yi, See Wei Yuan, Subramani Parasuraman, Sundram Karupiah. "Insignificant antidiabetic activities of ethanolic extracts of seeds of Archidendron pauciflorum." Journal of Pharmaceutical Negative Results 11.1 (2020), 47-53. Print. doi:10.4103/jpnr.JPNR_10_20



APA (American Psychological Association) Style

Sundarasekar Jeevandran, Sahgal Geethaa, Wong Jin Yi, See Wei Yuan, Subramani Parasuraman, Sundram Karupiah (2020) Insignificant antidiabetic activities of ethanolic extracts of seeds of Archidendron pauciflorum. Journal of Pharmaceutical Negative Results, 11 (1), 47-53. doi:10.4103/jpnr.JPNR_10_20