Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan

2021, Vol: 12, Issue: 2

12 / 2Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

Review Article

PNR. 2019; 10(1): 6-15

doi: 10.4103/jpnr.JPNR_3_19

Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan.

Abstract
Oxidative stress has been implicated in suicidal behavior and bipolar disorder (BD), respectively. However, the role of oxidative stress as a biomarker of suicidal behavior in BD remains inconclusive. This systematic review aims to determine the association between oxidative stress biomarkers and suicidal behavior among BD patients. All human studies from Scopus and Ovid Medline up until August 2017 on suicidal behavior, BD, and oxidative stress biomarkers were included according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A total of five studies met the eligibility criteria, of which 4 were case–control studies. Three studies identified at least one biomarker with significant association between suicidal acts and oxidative stress biomarkers (i.e., increased lipid peroxidation and NOS3 rs 1799983 TT genotype) in previous suicide attempt and increased deoxyribonucleic acid damage in suicide among sample populations with BD patients. No study reported conclusive associations between Ala-9 Val manganese superoxide dismutase or Pro 197 Leu glutathione peroxidase gene polymorphisms; or levels of nitric oxide metabolites, plasma total antioxidant potential, and malondialdehyde with suicidal acts among BD patients. Based on this systematic review, there is limited evidence of any association of the association between oxidative stress biomarkers and suicidal acts in BD patients. Definitive conclusions could not be ascertained due to lack of homogenous properly controlled and adequately powered studies. Future systematically well-designed and larger, prospective studies are warranted to clarify the role of oxidative stress pathways in the pathophysiology of suicidal behavior in BD.

Key words: Antioxidant, bipolar disorder, deoxyribonucleic acid damage, oxidative stress, suicidal behavior

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Nurul Ain Mohamad Kamal Articles by Jiann Lin Loo Articles by Jo Aan Goon Articles by Hanafi Ahmad Damanhuri Articles by Shalisah Sharip Articles by Suriati Mohamed Saini Articles by Jemaima Che Hamzah Articles by Lai Fong Chan
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan. Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review. PNR. 2019; 10(1): 6-15. doi:10.4103/jpnr.JPNR_3_19

Web Style

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan. Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review. http://www.pnrjournal.com/?mno=133428 [Access: January 26, 2022]. doi:10.4103/jpnr.JPNR_3_19

AMA (American Medical Association) Style

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan. Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review. PNR. 2019; 10(1): 6-15. doi:10.4103/jpnr.JPNR_3_19

Vancouver/ICMJE Style

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan. Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review. PNR. (2019), [cited January 26, 2022]; 10(1): 6-15. doi:10.4103/jpnr.JPNR_3_19

Harvard Style

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan (2019) Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review. PNR, 10 (1), 6-15. doi:10.4103/jpnr.JPNR_3_19

Turabian Style

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan. 2019. Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review. Journal of Pharmaceutical Negative Results, 10 (1), 6-15. doi:10.4103/jpnr.JPNR_3_19

Chicago Style

Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan. "Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review." Journal of Pharmaceutical Negative Results 10 (2019), 6-15. doi:10.4103/jpnr.JPNR_3_19

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Most Viewed Articles

Pharmacoepidemiology of Antiepileptic Drugs in Children
Darya Knyazeva, Yulia Gushchina, Oksana Zakharova
PNR. 2021; 12(1): 1-6
» Abstract » doi: 10.47750/pnr.2021.12.01.001

Comparative Benefits of Statins in Coronary Heart Disease
Viktoriya Ermakova, Hizir Bataev, Natalya Semenenko
PNR. 2021; 12(1): 7-13
» Abstract » doi: 10.47750/pnr.2021.12.01.002

Influence of polylactic acid and polycaprolactone on dissolution characteristics of ansamycin-loaded polymeric nanoparticles: An unsatisfied attempt for drug release profile
Keerthi GS Nair, Ramaiyan Velmurugan, Sathesh Kumar Sukumaran
PNR. 2020; 11(1): 23-29
» Abstract » doi: 10.4103/jpnr.JPNR_26_19

Oxidative stress biomarkers in bipolar disorder with suicidal behavior: A systematic review
Nurul Ain Mohamad Kamal, Jiann Lin Loo, Jo Aan Goon, Hanafi Ahmad Damanhuri, Shalisah Sharip, Suriati Mohamed Saini, Jemaima Che Hamzah, Lai Fong Chan
PNR. 2019; 10(1): 6-15
» Abstract » doi: 10.4103/jpnr.JPNR_3_19

Ethical Issues of Decision Making and Communication in Health Care: An Intercultural and Interfaith Perspective
Elena Grunt, Alexander Ivanov, Elena Zubko, Vladimir Starostin
PNR. 2021; 12(1): 27-32
» Abstract » doi: 10.47750/pnr.2021.12.01.005

Most Downloaded

Lack of activity of rutin isolated from Tontelea micrantha leaves against Vero and BHK, fungi, bacteria and Mayaro virus and its in silico activity
Waleska Stephanie Da Cruz Nizer, Ariane Coelho Ferraz, Thais De Fatima Silva Moraes, Fernanda Lopes Ferreira, Cintia Lopes De Brito Magalhães, Sidney Augusto Vieira-Filho, Lucenir Pains Duarte, José Carlos De Magalhães
PNR. 2020; 11(1): 9-14
» Abstract » doi: 10.4103/jpnr.JPNR_12_19

No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis
Thara Tunthanathip, Kantapong Mamueang, Nichapat Nilbupha, Chattarin Maliwan, Tanan Bejrananda
PNR. 2020; 11(1): 1-8
» Abstract » doi: 10.4103/jpnr.JPNR_22_19

Neurobehavioral activity study of methanolic whole plants extract of Cyperus rotundus Linn.
Imonul Kabir, Subir Biswas, Md Asaduzzaman, Md Islam Molla, Md Rajdoula Rafe
PNR. 2019; 10(1): 36-40
» Abstract » doi: 10.4103/jpnr.JPNR_11_19

Antimicrobial effect of chloroform Hibiscus sabdariffa extract on pathogenic bacteria
Elaheh Aleebrahim-Dehkordy, Mahmoud Rafieian-Kopaei, Behnam Zamanzad, Fatemeh Deris, Abolghasem Sharifih, Ali Reyhanian
PNR. 2020; 11(1): 15-18
» Abstract » doi: 10.4103/jpnr.JPNR_19_18

Antimicrobial resistance and presence of Class 1 integrons in Pseudomonas aeruginosa isolates from burn and wound infections
Ali Hassoun Hammadi, Qutaiba Ahmed Al Khames Aga, Nabil Awni Nimer, Pottathil Shinu, Anroop B Nair
PNR. 2020; 11(1): 19-22
» Abstract » doi: 10.4103/jpnr.JPNR_9_20

Most Cited Articles

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access. The articles in Journal of Pharmaceutical Negative Results are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

Copyright © 2022 Journal of Pharmaceutical Negative Results All Rights Reserved. Subject to change without notice from or liability to Journal of Pharmaceutical Negative Results. For best results, please use Internet Explorer or Google Chrome	Contact Information ResearchTrentz Scientific Research Community Contact US 21, First Floor, ResearchTrentz (Registred Office) Thamotharan Street, Tamilnadu - 636 009 Email : editor@pnrjournal.com, Support : pnrjournal@gmail.com

POLICIES & JOURNAL LINKS

Contact Information

How to cite this article