E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


Biological evaluation of certain plants of family salicaceae and arecaceae

Naglaa Ismail Afifi, Abeer Sayed Moawad, Mohamed Ahmed Zaki, Mona Hafez Hetta, Rabab Mohammed Mohammed.

Abstract
Objective: There is an increasing interest in the use of natural products to oppose human diseases. The leaves of Flacourtia rukam Zoll and A. Mortizi, Archontophoenix alexandrae (Wendl. and Drude), and Dictyosperma album (Bory) H. Wendl. and Drude ex. Scheff were selected for phytochemical and biological screening to search for new natural drugs. Total ethanolic extracts of the mentioned plants were subjected to preliminary phytochemical screening followed by screening their cytotoxic, antimalarial, antimicrobial, and anti-inflammatory activities. Materials and Methods: The extracts were tested for the presence of various phytochemicals. The cytotoxic activity was determined against five human cancer cell lines: melanoma, breast, oral, ovarian, and cervical cancers and two noncancerous cell lines. The antimalarial activity was determined against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum depending on the plasmodial lactate dehydrogenase activity. Antimicrobial screening was continued using the modified version of the CLSI method whereas anti-inflammatory activity was determined by measuring the activity of inducible nitric oxide synthase (iNOS). Results: Preliminary phytochemical screening indicated the absence of alkaloids, anthraquinones, and saponins in all the extracts. The latter showed no toxicity against the tested cancer cell lines and no activity against the tested microbes. The extract of D. album lacks the activity against D6 and showed a moderate activity against W2 P. falciparum (IC50= 41.7 μ/mL). D. album extract showed no inhibition for iNOS as contrary to F. rukam and A. alexandrae extracts which showed a good inhibition (IC50= 20 and 100 μ/mL, respectively). Conclusion: All tested extracts lack cytotoxic and antimicrobial activities.

Key words: Antimicrobial, Archontophoenix, cytotoxic, Dictyosperma, Flacourtia, inducible nitric oxide synthase


 
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How to Cite this Article
Pubmed Style

Naglaa Ismail Afifi, Abeer Sayed Moawad, Mohamed Ahmed Zaki, Mona Hafez Hetta, Rabab Mohammed Mohammed. Biological evaluation of certain plants of family salicaceae and arecaceae. PNR. 2019; 10(1): 32-35. doi:10.4103/jpnr.JPNR_12_18


Web Style

Naglaa Ismail Afifi, Abeer Sayed Moawad, Mohamed Ahmed Zaki, Mona Hafez Hetta, Rabab Mohammed Mohammed. Biological evaluation of certain plants of family salicaceae and arecaceae. https://www.pnrjournal.com/?mno=133448 [Access: April 20, 2022]. doi:10.4103/jpnr.JPNR_12_18


AMA (American Medical Association) Style

Naglaa Ismail Afifi, Abeer Sayed Moawad, Mohamed Ahmed Zaki, Mona Hafez Hetta, Rabab Mohammed Mohammed. Biological evaluation of certain plants of family salicaceae and arecaceae. PNR. 2019; 10(1): 32-35. doi:10.4103/jpnr.JPNR_12_18



Vancouver/ICMJE Style

Naglaa Ismail Afifi, Abeer Sayed Moawad, Mohamed Ahmed Zaki, Mona Hafez Hetta, Rabab Mohammed Mohammed. Biological evaluation of certain plants of family salicaceae and arecaceae. PNR. (2019), [cited April 20, 2022]; 10(1): 32-35. doi:10.4103/jpnr.JPNR_12_18



Harvard Style

Naglaa Ismail Afifi, Abeer Sayed Moawad, Mohamed Ahmed Zaki, Mona Hafez Hetta, Rabab Mohammed Mohammed (2019) Biological evaluation of certain plants of family salicaceae and arecaceae. PNR, 10 (1), 32-35. doi:10.4103/jpnr.JPNR_12_18



Turabian Style

Naglaa Ismail Afifi, Abeer Sayed Moawad, Mohamed Ahmed Zaki, Mona Hafez Hetta, Rabab Mohammed Mohammed. 2019. Biological evaluation of certain plants of family salicaceae and arecaceae. Journal of Pharmaceutical Negative Results, 10 (1), 32-35. doi:10.4103/jpnr.JPNR_12_18



Chicago Style

Naglaa Ismail Afifi, Abeer Sayed Moawad, Mohamed Ahmed Zaki, Mona Hafez Hetta, Rabab Mohammed Mohammed. "Biological evaluation of certain plants of family salicaceae and arecaceae." Journal of Pharmaceutical Negative Results 10 (2019), 32-35. doi:10.4103/jpnr.JPNR_12_18



MLA (The Modern Language Association) Style

Naglaa Ismail Afifi, Abeer Sayed Moawad, Mohamed Ahmed Zaki, Mona Hafez Hetta, Rabab Mohammed Mohammed. "Biological evaluation of certain plants of family salicaceae and arecaceae." Journal of Pharmaceutical Negative Results 10.1 (2019), 32-35. Print. doi:10.4103/jpnr.JPNR_12_18



APA (American Psychological Association) Style

Naglaa Ismail Afifi, Abeer Sayed Moawad, Mohamed Ahmed Zaki, Mona Hafez Hetta, Rabab Mohammed Mohammed (2019) Biological evaluation of certain plants of family salicaceae and arecaceae. Journal of Pharmaceutical Negative Results, 10 (1), 32-35. doi:10.4103/jpnr.JPNR_12_18