E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


The value of lisnopril in managing impaired fertility in experimental rats following alloxan induced hyperglycemia

Mohammed j Manna, Murtadha S Jabur.

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  • Abstract
    Background: It has been shown that the chronic metabolic derangement accompanying long standing hyperglycemia, both in experimental animals and man, may alter fertility in males. This work investigate the role of lisnopril in improving fertility parameters .
    Aim of the study: To evaluate the role of lisnopril with respect to fertility parameters in experimentally induced hyperglycemia in rats.
    Materials and methods: Three groups of rats were subjected to alloxan induced hyperglycemia, placebo treatment (control group), and alloxan and lisnopril treatment (study group). Each group included 10 animals. Sperm parameters, hormonal levels, markers of oxidative stress and histophotometry were done .
    Results: Sperm parameters in the form of sperm count, normal morphology, motility and number of dead sperms were significantly altered following alloxan induced hyperglycemia (P < 0.001). The administration of lisnopril showed significant improvement in sperm parameters (P <0.001) in addition to significant improvement in markers of oxidative stress, GSH, SOD, MDA and NO (P < 0.001), and in hormonal levels, testosterone and FSH (P < 0.001).
    Conclusion: Lisnopril is useful in optimizing fertility parameters in experimental rats following alloxan induced hyperglycemia through antioxidant mechanisms and improved hormonal profile.

    Key words: Alloxan, Hyperglycemia, lisnopril, male infertility


     
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    How to Cite this Article
    Pubmed Style

    Manna Mj, Jabur MS. The value of lisnopril in managing impaired fertility in experimental rats following alloxan induced hyperglycemia. PNR. 2021; 12(2): 18-23. doi:10.47750/pnr.2021.12.02.003


    Web Style

    Manna Mj, Jabur MS. The value of lisnopril in managing impaired fertility in experimental rats following alloxan induced hyperglycemia. https://www.pnrjournal.com/?mno=138305 [Access: August 11, 2022]. doi:10.47750/pnr.2021.12.02.003


    AMA (American Medical Association) Style

    Manna Mj, Jabur MS. The value of lisnopril in managing impaired fertility in experimental rats following alloxan induced hyperglycemia. PNR. 2021; 12(2): 18-23. doi:10.47750/pnr.2021.12.02.003



    Vancouver/ICMJE Style

    Manna Mj, Jabur MS. The value of lisnopril in managing impaired fertility in experimental rats following alloxan induced hyperglycemia. PNR. (2021), [cited August 11, 2022]; 12(2): 18-23. doi:10.47750/pnr.2021.12.02.003



    Harvard Style

    Manna, M. j. & Jabur, . M. S. (2021) The value of lisnopril in managing impaired fertility in experimental rats following alloxan induced hyperglycemia. PNR, 12 (2), 18-23. doi:10.47750/pnr.2021.12.02.003



    Turabian Style

    Manna, Mohammed j, and Murtadha S Jabur. 2021. The value of lisnopril in managing impaired fertility in experimental rats following alloxan induced hyperglycemia. Journal of Pharmaceutical Negative Results, 12 (2), 18-23. doi:10.47750/pnr.2021.12.02.003



    Chicago Style

    Manna, Mohammed j, and Murtadha S Jabur. "The value of lisnopril in managing impaired fertility in experimental rats following alloxan induced hyperglycemia." Journal of Pharmaceutical Negative Results 12 (2021), 18-23. doi:10.47750/pnr.2021.12.02.003



    MLA (The Modern Language Association) Style

    Manna, Mohammed j, and Murtadha S Jabur. "The value of lisnopril in managing impaired fertility in experimental rats following alloxan induced hyperglycemia." Journal of Pharmaceutical Negative Results 12.2 (2021), 18-23. Print. doi:10.47750/pnr.2021.12.02.003



    APA (American Psychological Association) Style

    Manna, M. j. & Jabur, . M. S. (2021) The value of lisnopril in managing impaired fertility in experimental rats following alloxan induced hyperglycemia. Journal of Pharmaceutical Negative Results, 12 (2), 18-23. doi:10.47750/pnr.2021.12.02.003