E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


A Comparative Study of Safety and Efficacy of Metformin Monotherapy Against Teneligliptin and Metformin in Type 2 Diabetes Mellitus

Poornima R, BRIGIDA S, Arul Amutha Elizabeth L, Soujania singh G, Tanuja Lella.

Abstract
INTRODUCTION: Diabetes mellitus is a metabolic disorder characterised by hyperglycaemia and abnormalities in simple carbohydrate, fat, and protein metabolism. Diabetes mellitus control can only be achieved by diet, exercise, regular sleep pattern then with addition of anti-hyperglycemic drugs like metformin, if glycated hemoglobin (HbA1C) is above 7.0%. MATERIALS & METHODS: The study period was from April 2019 – September 2019. The total duration of study was 24 weeks. Total 160 patients were screened; among them 100 participants were selected as per the inclusion criteria. RESULTS: Out of 100 patients, only 91 patients have completed the study. Having perceived so much about the weightage of monotherapy with metformin, this study revealed the non-inferiority of dual therapy. CONCLUSION: To conclude dipeptidyl peptidase-4(DPP-4) inhibitor Teneligliptin 20mg OD with Metformin 500mg two times a day (BD) serves the purpose of enhancing the glycaemic control and stands to be an efficacious treatment of type 2 diabetes mellitus with better compliance and acceptability.

Key words: Metformin Monotherapy, Non-inferiority study, Teneligliptin and metformin dual therapy, Type 2 Diabetes Mellitus.


 
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How to Cite this Article
Pubmed Style

R P, S B, L AAE, G Ss, Lella T. A Comparative Study of Safety and Efficacy of Metformin Monotherapy Against Teneligliptin and Metformin in Type 2 Diabetes Mellitus. PNR. 2022; 13(2): 7-12. doi:10.47750/pnr.2022.13.02.002


Web Style

R P, S B, L AAE, G Ss, Lella T. A Comparative Study of Safety and Efficacy of Metformin Monotherapy Against Teneligliptin and Metformin in Type 2 Diabetes Mellitus. https://www.pnrjournal.com/?mno=138754 [Access: August 11, 2022]. doi:10.47750/pnr.2022.13.02.002


AMA (American Medical Association) Style

R P, S B, L AAE, G Ss, Lella T. A Comparative Study of Safety and Efficacy of Metformin Monotherapy Against Teneligliptin and Metformin in Type 2 Diabetes Mellitus. PNR. 2022; 13(2): 7-12. doi:10.47750/pnr.2022.13.02.002



Vancouver/ICMJE Style

R P, S B, L AAE, G Ss, Lella T. A Comparative Study of Safety and Efficacy of Metformin Monotherapy Against Teneligliptin and Metformin in Type 2 Diabetes Mellitus. PNR. (2022), [cited August 11, 2022]; 13(2): 7-12. doi:10.47750/pnr.2022.13.02.002



Harvard Style

R, P., S, . B., L, . A. A. E., G, . S. s. & Lella, . T. (2022) A Comparative Study of Safety and Efficacy of Metformin Monotherapy Against Teneligliptin and Metformin in Type 2 Diabetes Mellitus. PNR, 13 (2), 7-12. doi:10.47750/pnr.2022.13.02.002



Turabian Style

R, Poornima, BRIGIDA S, Arul Amutha Elizabeth L, Soujania singh G, and Tanuja Lella. 2022. A Comparative Study of Safety and Efficacy of Metformin Monotherapy Against Teneligliptin and Metformin in Type 2 Diabetes Mellitus. Journal of Pharmaceutical Negative Results, 13 (2), 7-12. doi:10.47750/pnr.2022.13.02.002



Chicago Style

R, Poornima, BRIGIDA S, Arul Amutha Elizabeth L, Soujania singh G, and Tanuja Lella. "A Comparative Study of Safety and Efficacy of Metformin Monotherapy Against Teneligliptin and Metformin in Type 2 Diabetes Mellitus." Journal of Pharmaceutical Negative Results 13 (2022), 7-12. doi:10.47750/pnr.2022.13.02.002



MLA (The Modern Language Association) Style

R, Poornima, BRIGIDA S, Arul Amutha Elizabeth L, Soujania singh G, and Tanuja Lella. "A Comparative Study of Safety and Efficacy of Metformin Monotherapy Against Teneligliptin and Metformin in Type 2 Diabetes Mellitus." Journal of Pharmaceutical Negative Results 13.2 (2022), 7-12. Print. doi:10.47750/pnr.2022.13.02.002



APA (American Psychological Association) Style

R, P., S, . B., L, . A. A. E., G, . S. s. & Lella, . T. (2022) A Comparative Study of Safety and Efficacy of Metformin Monotherapy Against Teneligliptin and Metformin in Type 2 Diabetes Mellitus. Journal of Pharmaceutical Negative Results, 13 (2), 7-12. doi:10.47750/pnr.2022.13.02.002