Studying The Impact of Plasminogen Activator Inhibitor -1 and Some Biochemical Parameters In Iraqi Children with  Type -1 Diabetes Mellitus

Muthana Anad Majid; Wassan Abdul Kareem Abbas; Huda Jaber Waheed

doi:10.47750/pnr.2022.13.01.007

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Original Article

PNR. 2022; 13(1): 35-38

doi: 10.47750/pnr.2022.13.01.007

Studying The Impact of Plasminogen Activator Inhibitor -1 and Some Biochemical Parameters In Iraqi Children with Type -1 Diabetes Mellitus

Muthana Anad Majid, Wassan Abdul Kareem Abbas, Huda Jaber Waheed.

Abstract
Background: Type 1 diabetes mellitus (T1DM) defined as is a metabolic disease , featuring by hyperglycaemia, because of the insulin deficiency that occurs due to loss of the pancreatic islet β-cells . several studies in humans found that There were a relation between increase plasminogen activator inhibitor-1 (PAI-1) concentrations with obesity 12, insulin resistance 13, impaired glucose tolerance . Serum PAI-1 was raised primarily at the level of impaired glucose tolerance arriving to DM.
Material and Methods: Total of (30) T1DM patients from Baghdad were participate in this study. Blood and serum samples were obtained for the estimation of HbA1C and serum PAI, FBG, albumin, total bilirubin levels.
Results: The pooled data of participants showed a positive correlation between PAI and each of and each of age ,gender ,FBG,Total bilirubin (r= -0.128, P=0.402,p=0.027,p=0.121) .The negative correlation of PAI with each of HbA1C ,albumin (r= -0.180, P= -0.151). was reported in participants . The study did not report a significant correlation between other parameters
Conclusion: Current study clarify that the prevalence of T1DM in male is higher than female among Iraqi children. There is significant increase in serum PAI-1 in diabetic patients when compared with control . Serum bilirubin levels of diabetic patients were significantly higher than that of healthy subjects and albumin levels were lower than normal subjects . A positive correlation between the mean of PAI-1 with both gender and age ,while a negative correlation between PAI-1 , albumin and HbA1c was demonstrated in this study.

Key words: Type 1 diabetes mellitus , Plasminogen Activator Inhibitor, HbA1C, Albumin , Bilirubin

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Pubmed Style

Majid MA, WAKA, Waheed HJ. Studying The Impact of Plasminogen Activator Inhibitor -1 and Some Biochemical Parameters In Iraqi Children with Type -1 Diabetes Mellitus. PNR. 2022; 13(1): 35-38. doi:10.47750/pnr.2022.13.01.007

Web Style

Majid MA, WAKA, Waheed HJ. Studying The Impact of Plasminogen Activator Inhibitor -1 and Some Biochemical Parameters In Iraqi Children with Type -1 Diabetes Mellitus. https://www.pnrjournal.com/?mno=20898 [Access: April 20, 2022]. doi:10.47750/pnr.2022.13.01.007

AMA (American Medical Association) Style

Majid MA, WAKA, Waheed HJ. Studying The Impact of Plasminogen Activator Inhibitor -1 and Some Biochemical Parameters In Iraqi Children with Type -1 Diabetes Mellitus. PNR. 2022; 13(1): 35-38. doi:10.47750/pnr.2022.13.01.007

Vancouver/ICMJE Style

Majid MA, WAKA, Waheed HJ. Studying The Impact of Plasminogen Activator Inhibitor -1 and Some Biochemical Parameters In Iraqi Children with Type -1 Diabetes Mellitus. PNR. (2022), [cited April 20, 2022]; 13(1): 35-38. doi:10.47750/pnr.2022.13.01.007

Harvard Style

Majid, M. A., , . W. A. K. A. & Waheed, . H. J. (2022) Studying The Impact of Plasminogen Activator Inhibitor -1 and Some Biochemical Parameters In Iraqi Children with Type -1 Diabetes Mellitus. PNR, 13 (1), 35-38. doi:10.47750/pnr.2022.13.01.007

Turabian Style

Majid, Muthana Anad, Wassan Abdul Kareem Abbas, and Huda Jaber Waheed. 2022. Studying The Impact of Plasminogen Activator Inhibitor -1 and Some Biochemical Parameters In Iraqi Children with Type -1 Diabetes Mellitus. Journal of Pharmaceutical Negative Results, 13 (1), 35-38. doi:10.47750/pnr.2022.13.01.007

Chicago Style

Majid, Muthana Anad, Wassan Abdul Kareem Abbas, and Huda Jaber Waheed. "Studying The Impact of Plasminogen Activator Inhibitor -1 and Some Biochemical Parameters In Iraqi Children with Type -1 Diabetes Mellitus." Journal of Pharmaceutical Negative Results 13 (2022), 35-38. doi:10.47750/pnr.2022.13.01.007

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Majid, M. A., , . W. A. K. A. & Waheed, . H. J. (2022) Studying The Impact of Plasminogen Activator Inhibitor -1 and Some Biochemical Parameters In Iraqi Children with Type -1 Diabetes Mellitus. Journal of Pharmaceutical Negative Results, 13 (1), 35-38. doi:10.47750/pnr.2022.13.01.007

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