E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


Ethanolic Extract of Moringa oleifera Leaves Ameliorates TNF- and IL-8 Level from Rat Model of S. Aureus-Induced Rhinosinusitis

Andriana T. W. Wardani*, Bambang Purwanto, Dono Indarto, Brian Wasita, Risya Cilmiaty AR.

Abstract
Background: Acute bacterial rhinosinusitis is a common complication that require antibiotic therapy to recover promptly. To avoid the
emergence and spread of antibiotic-resistant bacteria, Ethanol extract of moringa leaves (EEDK) contains active ingredients that serve as
antioxidants that can help restore redox metabolic balance and can reduce excess free radicals so as to prevent oxidative stress and speed
healing.
Materials and Method: Effect of moringa leaves ethanol was evaluated in difference day post treatment, day 7th and day 10th. The level of
TNF-a and IL-8 from each treatment group in Staphylococcus aureus rhinosinusitis induced rat was evaluated using ELISA compared to
control group. Data were analyzed using SPSS 25.0 for Windows.
Result: The results of the analysis of different tests of T-Test independence can be concluded that there is decrease in the average level
of TNF-α on the 7th day with the 10th day in the P2 and P4 groups there is significant difference (p-value = 0.000), while the P3 group
decreased the level of TNF-α on the 7th day with the 10th day there was no significant difference (p-value = 0.630), while the results of the
il-8 independence difference in the average il-8 level decrease on the 7th day with the 10th day in Group P2, P3, P4 there is a significant
difference (p-value =0.000).
Conclusion: The combination of Amoxicillin 27 mg/day and EEDK 100mg/kg is better at decreasing TNF-α and IL-8 levels during 10 days
of administration. EEDK can be used as an adjuvant therapy for acute bacterial rhinosinusitis.

Key words: Ethanol, moringa leaves, rhinosinusitis, TNF-α, IL8.


 
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How to Cite this Article
Pubmed Style

Wardani ATW, Purwanto B, Indarto D, Wasita B, AR RC. Ethanolic Extract of Moringa oleifera Leaves Ameliorates TNF- and IL-8 Level from Rat Model of S. Aureus-Induced Rhinosinusitis. PNR. 2022; 13(1): 25-29. doi:10.47750/pnr.2022.13.01.005


Web Style

Wardani ATW, Purwanto B, Indarto D, Wasita B, AR RC. Ethanolic Extract of Moringa oleifera Leaves Ameliorates TNF- and IL-8 Level from Rat Model of S. Aureus-Induced Rhinosinusitis. https://www.pnrjournal.com/?mno=28206 [Access: April 20, 2022]. doi:10.47750/pnr.2022.13.01.005


AMA (American Medical Association) Style

Wardani ATW, Purwanto B, Indarto D, Wasita B, AR RC. Ethanolic Extract of Moringa oleifera Leaves Ameliorates TNF- and IL-8 Level from Rat Model of S. Aureus-Induced Rhinosinusitis. PNR. 2022; 13(1): 25-29. doi:10.47750/pnr.2022.13.01.005



Vancouver/ICMJE Style

Wardani ATW, Purwanto B, Indarto D, Wasita B, AR RC. Ethanolic Extract of Moringa oleifera Leaves Ameliorates TNF- and IL-8 Level from Rat Model of S. Aureus-Induced Rhinosinusitis. PNR. (2022), [cited April 20, 2022]; 13(1): 25-29. doi:10.47750/pnr.2022.13.01.005



Harvard Style

Wardani, A. T. W., Purwanto, . B., Indarto, . D., Wasita, . B. & AR, . R. C. (2022) Ethanolic Extract of Moringa oleifera Leaves Ameliorates TNF- and IL-8 Level from Rat Model of S. Aureus-Induced Rhinosinusitis. PNR, 13 (1), 25-29. doi:10.47750/pnr.2022.13.01.005



Turabian Style

Wardani, Andriana T. W., Bambang Purwanto, Dono Indarto, Brian Wasita, and Risya Cilmiaty AR. 2022. Ethanolic Extract of Moringa oleifera Leaves Ameliorates TNF- and IL-8 Level from Rat Model of S. Aureus-Induced Rhinosinusitis. Journal of Pharmaceutical Negative Results, 13 (1), 25-29. doi:10.47750/pnr.2022.13.01.005



Chicago Style

Wardani, Andriana T. W., Bambang Purwanto, Dono Indarto, Brian Wasita, and Risya Cilmiaty AR. "Ethanolic Extract of Moringa oleifera Leaves Ameliorates TNF- and IL-8 Level from Rat Model of S. Aureus-Induced Rhinosinusitis." Journal of Pharmaceutical Negative Results 13 (2022), 25-29. doi:10.47750/pnr.2022.13.01.005



MLA (The Modern Language Association) Style

Wardani, Andriana T. W., Bambang Purwanto, Dono Indarto, Brian Wasita, and Risya Cilmiaty AR. "Ethanolic Extract of Moringa oleifera Leaves Ameliorates TNF- and IL-8 Level from Rat Model of S. Aureus-Induced Rhinosinusitis." Journal of Pharmaceutical Negative Results 13.1 (2022), 25-29. Print. doi:10.47750/pnr.2022.13.01.005



APA (American Psychological Association) Style

Wardani, A. T. W., Purwanto, . B., Indarto, . D., Wasita, . B. & AR, . R. C. (2022) Ethanolic Extract of Moringa oleifera Leaves Ameliorates TNF- and IL-8 Level from Rat Model of S. Aureus-Induced Rhinosinusitis. Journal of Pharmaceutical Negative Results, 13 (1), 25-29. doi:10.47750/pnr.2022.13.01.005