E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


Investigation of Relationship Between (rs9923231) SNP in (VKORC1) Gene with Incidence of COVID-19

Hams Hussain Hashim Al-Fattli, Tabarek Salam Abd-Alraoof.

Abstract
Coronavirus disease-2019 (COVID-19) is a devastating pandemic caused by coronavirus two infections characterized by severe acute respiratory syndrome (SARS). It is also known as the SARS pandemic (SARS-CoV-2). Despite the release of a spate of vaccinations to protect against coronavirus infection 2019 (COVID-19) in recent years, a cure for the ailment remains elusive. Thrombosis is one of the consequences of the Coronavirus disease of 2019 (COVID-19), and it is frequently associated with a poor prognosis in the affected population. Inflammation and coagulation are well-known to be related to one another; nevertheless, more investigation on the number of thrombotic events associated with COVID-19 is required. Evidence suggests that proteins linked with coagulation interact with SARS-related proteins. The frequency variants of each of correlated proteins across different populations may be questioned about their probable involvement in the development of COVID-19. Using 50 patients and 25 control samples, we studied the connection between a single nucleotide polymorphism (SNP) (rs9923231) in the Vit. K epoxide reductase complex 1 (VKORC1) gene and the presence of COVI-19 in order to establish a potential genetic biomarker for COVID-19. An ARMS PCR was carried out to determine the percent of SNPs in each of the three groups. Following the analysis of 75 samples, the data indicated no statistically significant changes between the case and control groups (P. value 0.5).

Key words: COVID-19, rs9923231, VKORC1-1639G>A, Vitamin K, SNPs


 
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How to Cite this Article
Pubmed Style

HHHA, Abd-Alraoof TS. Investigation of Relationship Between (rs9923231) SNP in (VKORC1) Gene with Incidence of COVID-19. PNR. 2022; 13(2): 23-31. doi:10.47750/pnr.2022.13.02.004


Web Style

HHHA, Abd-Alraoof TS. Investigation of Relationship Between (rs9923231) SNP in (VKORC1) Gene with Incidence of COVID-19. https://www.pnrjournal.com/?mno=30183 [Access: August 11, 2022]. doi:10.47750/pnr.2022.13.02.004


AMA (American Medical Association) Style

HHHA, Abd-Alraoof TS. Investigation of Relationship Between (rs9923231) SNP in (VKORC1) Gene with Incidence of COVID-19. PNR. 2022; 13(2): 23-31. doi:10.47750/pnr.2022.13.02.004



Vancouver/ICMJE Style

HHHA, Abd-Alraoof TS. Investigation of Relationship Between (rs9923231) SNP in (VKORC1) Gene with Incidence of COVID-19. PNR. (2022), [cited August 11, 2022]; 13(2): 23-31. doi:10.47750/pnr.2022.13.02.004



Harvard Style

, H. H. H. A. & Abd-Alraoof, . T. S. (2022) Investigation of Relationship Between (rs9923231) SNP in (VKORC1) Gene with Incidence of COVID-19. PNR, 13 (2), 23-31. doi:10.47750/pnr.2022.13.02.004



Turabian Style

, Hams Hussain Hashim Al-Fattli, and Tabarek Salam Abd-Alraoof. 2022. Investigation of Relationship Between (rs9923231) SNP in (VKORC1) Gene with Incidence of COVID-19. Journal of Pharmaceutical Negative Results, 13 (2), 23-31. doi:10.47750/pnr.2022.13.02.004



Chicago Style

, Hams Hussain Hashim Al-Fattli, and Tabarek Salam Abd-Alraoof. "Investigation of Relationship Between (rs9923231) SNP in (VKORC1) Gene with Incidence of COVID-19." Journal of Pharmaceutical Negative Results 13 (2022), 23-31. doi:10.47750/pnr.2022.13.02.004



MLA (The Modern Language Association) Style

, Hams Hussain Hashim Al-Fattli, and Tabarek Salam Abd-Alraoof. "Investigation of Relationship Between (rs9923231) SNP in (VKORC1) Gene with Incidence of COVID-19." Journal of Pharmaceutical Negative Results 13.2 (2022), 23-31. Print. doi:10.47750/pnr.2022.13.02.004



APA (American Psychological Association) Style

, H. H. H. A. & Abd-Alraoof, . T. S. (2022) Investigation of Relationship Between (rs9923231) SNP in (VKORC1) Gene with Incidence of COVID-19. Journal of Pharmaceutical Negative Results, 13 (2), 23-31. doi:10.47750/pnr.2022.13.02.004