E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


DNA Repair Genes (APE1 and XRCC1) Polymorphisms – Cadmium interaction in Fuel Station Workers

Aizhar Hamzih Hasan, Noor Abdul Redah Al-Kremy, Marwa Fadhil Alsaffar, Mohammed Abed Jawad, Mona N. Al-Terehi.

Abstract
The interaction between heavy metals in the environment and DNA still under investigation, the association of cadmium and DNA repair was conducted in a current study represented by apurinic/apyrimidinic endonuclease (APE1) Asp148Glu (rs3136820) and X-ray repair cross-complementing group 1(XRCC1) Arg399Gln (28152) G>A, using CTTP-PCR, results showed non-significant changes of Cd (p 0.965) in the station workers and the control group. The Cd level in station workers according to work type showed non-significant differences (p 0.291). The APE1 genotyping in study groups showed significant association with all genotypes in station workers (p 0.009, p 0.024), non-significant association with allele frequency (p 0.066). The association XRCC 1 genotyping showed non-significant results (p 0.479, 0.0311), and non-significant with allele frequency (p 0.164). The distribution of APE 1 and XRCC 1 genotyping in the station workers according to work types showed non-significant association with APE 1 (p 0. 255), and significant with allele frequency (p 0.000). The XRCC1 showed non-significant association of GA, GG and workers (p 0.265) and significant association of G allele (p 0.001). The Cd levels, according to APE 1and XRCC1 genotyping showed non-significant differences (p 0.193, p 0.0.76) respectively. conclusion: a significant association of APE 1 with station workers, but didn’t association with Cd level and non-significant association of XRCC 1 genotyping with station works and Cd level.

Key words: DNA repair enzymes genes polymorphisms, APE1, XRCC1, cadmium level, fuel station workers.


 
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How to Cite this Article
Pubmed Style

Hasan AH, Al-Kremy NAR, Alsaffar MF, Jawad MA, Al-Terehi MN. DNA Repair Genes (APE1 and XRCC1) Polymorphisms – Cadmium interaction in Fuel Station Workers. PNR. 2022; 13(2): 32-37. doi:10.47750/pnr.2022.13.02.005


Web Style

Hasan AH, Al-Kremy NAR, Alsaffar MF, Jawad MA, Al-Terehi MN. DNA Repair Genes (APE1 and XRCC1) Polymorphisms – Cadmium interaction in Fuel Station Workers. https://www.pnrjournal.com/?mno=31314 [Access: August 11, 2022]. doi:10.47750/pnr.2022.13.02.005


AMA (American Medical Association) Style

Hasan AH, Al-Kremy NAR, Alsaffar MF, Jawad MA, Al-Terehi MN. DNA Repair Genes (APE1 and XRCC1) Polymorphisms – Cadmium interaction in Fuel Station Workers. PNR. 2022; 13(2): 32-37. doi:10.47750/pnr.2022.13.02.005



Vancouver/ICMJE Style

Hasan AH, Al-Kremy NAR, Alsaffar MF, Jawad MA, Al-Terehi MN. DNA Repair Genes (APE1 and XRCC1) Polymorphisms – Cadmium interaction in Fuel Station Workers. PNR. (2022), [cited August 11, 2022]; 13(2): 32-37. doi:10.47750/pnr.2022.13.02.005



Harvard Style

Hasan, A. H., Al-Kremy, . N. A. R., Alsaffar, . M. F., Jawad, . M. A. & Al-Terehi, . M. N. (2022) DNA Repair Genes (APE1 and XRCC1) Polymorphisms – Cadmium interaction in Fuel Station Workers. PNR, 13 (2), 32-37. doi:10.47750/pnr.2022.13.02.005



Turabian Style

Hasan, Aizhar Hamzih, Noor Abdul Redah Al-Kremy, Marwa Fadhil Alsaffar, Mohammed Abed Jawad, and Mona N. Al-Terehi. 2022. DNA Repair Genes (APE1 and XRCC1) Polymorphisms – Cadmium interaction in Fuel Station Workers. Journal of Pharmaceutical Negative Results, 13 (2), 32-37. doi:10.47750/pnr.2022.13.02.005



Chicago Style

Hasan, Aizhar Hamzih, Noor Abdul Redah Al-Kremy, Marwa Fadhil Alsaffar, Mohammed Abed Jawad, and Mona N. Al-Terehi. "DNA Repair Genes (APE1 and XRCC1) Polymorphisms – Cadmium interaction in Fuel Station Workers." Journal of Pharmaceutical Negative Results 13 (2022), 32-37. doi:10.47750/pnr.2022.13.02.005



MLA (The Modern Language Association) Style

Hasan, Aizhar Hamzih, Noor Abdul Redah Al-Kremy, Marwa Fadhil Alsaffar, Mohammed Abed Jawad, and Mona N. Al-Terehi. "DNA Repair Genes (APE1 and XRCC1) Polymorphisms – Cadmium interaction in Fuel Station Workers." Journal of Pharmaceutical Negative Results 13.2 (2022), 32-37. Print. doi:10.47750/pnr.2022.13.02.005



APA (American Psychological Association) Style

Hasan, A. H., Al-Kremy, . N. A. R., Alsaffar, . M. F., Jawad, . M. A. & Al-Terehi, . M. N. (2022) DNA Repair Genes (APE1 and XRCC1) Polymorphisms – Cadmium interaction in Fuel Station Workers. Journal of Pharmaceutical Negative Results, 13 (2), 32-37. doi:10.47750/pnr.2022.13.02.005