E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


Synthesis, Characterization and Antibacterial Evaluation of New Schiff Base Ligand and Its Complexes of Transition Metal Ion Zn (II), based on 6-Aminopenicillanic Acid

Mays S. Obaid, Sadiq A. Karim, Mohammed H. Said.

Abstract
In the present research, 6-aminopenicillanic acid (6-APA) reaction with(n-butyl aldehyde, crotonaldehyde, terephthalaldehyde, furfuraldehyde) in ethanol to procure compounds [6-(butylidene amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid, 6-(but-2-1-ylideneamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6,6’-((1,4-phenylenebis (methaneylylidene))bis(azaneylylidene))bis(3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid, 6-((furan-2-ylmethylene)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid] respectively. The structure of synthesized compounds identified by spectral data (FT-IR), ( 1H-NMR), (13C-NMR) spectra and Mass Spectrometric. The Schiff base ligand and synthesis some transition metals complexes [Zn] of this ligand were described via FTIR, UV-Visible Spectroscopy and the Atomic Absorption Spectroscopy, The antibacterial activity of the ligand and complexes was tested against two different bacteria strains (Pseudomonas and Staphylococcus aureus). The ligand and its complexes were discovered to have excellent inhibitory action against bacteria (Pseudomonas and Staphylococcus aureus). As a consequence

Key words: Schiff base, 6-amino penicillanic acid, Schiff base of n-butylaldehyde,Schiff base of crotonaldehyde, Schiff base of terephthaldehyde, Schiff base of furfural


 
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How to Cite this Article
Pubmed Style

Obaid MS, Karim SA, Said MH. Synthesis, Characterization and Antibacterial Evaluation of New Schiff Base Ligand and Its Complexes of Transition Metal Ion Zn (II), based on 6-Aminopenicillanic Acid. PNR. 2022; 13(2): 97-101. doi:10.47750/pnr.2022.13.02.015


Web Style

Obaid MS, Karim SA, Said MH. Synthesis, Characterization and Antibacterial Evaluation of New Schiff Base Ligand and Its Complexes of Transition Metal Ion Zn (II), based on 6-Aminopenicillanic Acid. https://www.pnrjournal.com/?mno=55954 [Access: August 11, 2022]. doi:10.47750/pnr.2022.13.02.015


AMA (American Medical Association) Style

Obaid MS, Karim SA, Said MH. Synthesis, Characterization and Antibacterial Evaluation of New Schiff Base Ligand and Its Complexes of Transition Metal Ion Zn (II), based on 6-Aminopenicillanic Acid. PNR. 2022; 13(2): 97-101. doi:10.47750/pnr.2022.13.02.015



Vancouver/ICMJE Style

Obaid MS, Karim SA, Said MH. Synthesis, Characterization and Antibacterial Evaluation of New Schiff Base Ligand and Its Complexes of Transition Metal Ion Zn (II), based on 6-Aminopenicillanic Acid. PNR. (2022), [cited August 11, 2022]; 13(2): 97-101. doi:10.47750/pnr.2022.13.02.015



Harvard Style

Obaid, M. S., Karim, . S. A. & Said, . M. H. (2022) Synthesis, Characterization and Antibacterial Evaluation of New Schiff Base Ligand and Its Complexes of Transition Metal Ion Zn (II), based on 6-Aminopenicillanic Acid. PNR, 13 (2), 97-101. doi:10.47750/pnr.2022.13.02.015



Turabian Style

Obaid, Mays S., Sadiq A. Karim, and Mohammed H. Said. 2022. Synthesis, Characterization and Antibacterial Evaluation of New Schiff Base Ligand and Its Complexes of Transition Metal Ion Zn (II), based on 6-Aminopenicillanic Acid. Journal of Pharmaceutical Negative Results, 13 (2), 97-101. doi:10.47750/pnr.2022.13.02.015



Chicago Style

Obaid, Mays S., Sadiq A. Karim, and Mohammed H. Said. "Synthesis, Characterization and Antibacterial Evaluation of New Schiff Base Ligand and Its Complexes of Transition Metal Ion Zn (II), based on 6-Aminopenicillanic Acid." Journal of Pharmaceutical Negative Results 13 (2022), 97-101. doi:10.47750/pnr.2022.13.02.015



MLA (The Modern Language Association) Style

Obaid, Mays S., Sadiq A. Karim, and Mohammed H. Said. "Synthesis, Characterization and Antibacterial Evaluation of New Schiff Base Ligand and Its Complexes of Transition Metal Ion Zn (II), based on 6-Aminopenicillanic Acid." Journal of Pharmaceutical Negative Results 13.2 (2022), 97-101. Print. doi:10.47750/pnr.2022.13.02.015



APA (American Psychological Association) Style

Obaid, M. S., Karim, . S. A. & Said, . M. H. (2022) Synthesis, Characterization and Antibacterial Evaluation of New Schiff Base Ligand and Its Complexes of Transition Metal Ion Zn (II), based on 6-Aminopenicillanic Acid. Journal of Pharmaceutical Negative Results, 13 (2), 97-101. doi:10.47750/pnr.2022.13.02.015