E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


DMF Attenuates Ciprofloxacin-Induced Nephropathy in Rats via Nrf2 Pathway

Saif M. Hassan, Raid M Al Abood, Mohammed Jasim Jawad, Mahmood J. Jawad, Nagham Al-Zubidi.

Abstract
Background: The pathophysiology of ciprofloxacin-induced nephropathy (CIN) is complicated by oxidative stress. The goal of this study
was to see if Dimethyl Fumarate (DMF) has any antioxidant properties in a rat model of CIN.
Methods: Rats were randomly assigned to six groups (n=8): control, ciprofloxacin (ciprofloxacin-induced CIN), two DMF groups (rats
treated with DMF 50mg and 100mg), and two ciprofloxacin Plus DMF groups (n=8/group) (CIN rats treated with DMF at 50 mg and 100
mg). Renal function testing, Nrf2 analysis, and anti-oxidant enzymes analysis was all done. Results: Following ciprofloxacin therapy, serum
blood urea nitrogen (BUN), creatinine, and anti-oxidant enzymes all rose. In the ciprofloxacin + DMF groups, serum BUN and creatinine
were lower, and anti-oxidant enzymes were higher than in the ciprofloxacin group, in CIN rats, DMF upregulated Nrf2 expression.
Conclusions: In vivo, DMF reduces experimental CIN. It’s thought that this impact activates the Nrf2 antioxidant defenses pathway.

Key words: Anti-oxidants, Ciprofloxacin, Creatinine, Nrf2, Urea.


 
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How to Cite this Article
Pubmed Style

Saif M. Hassan, Raid M Al Abood, Mohammed Jasim Jawad, Mahmood J. Jawad, Nagham Al-Zubidi. DMF Attenuates Ciprofloxacin-Induced Nephropathy in Rats via Nrf2 Pathway. PNR. 2022; 13(2): 87-91. doi:10.47750/pnr.2022.13.02.013


Web Style

Saif M. Hassan, Raid M Al Abood, Mohammed Jasim Jawad, Mahmood J. Jawad, Nagham Al-Zubidi. DMF Attenuates Ciprofloxacin-Induced Nephropathy in Rats via Nrf2 Pathway. https://www.pnrjournal.com/?mno=64213 [Access: August 11, 2022]. doi:10.47750/pnr.2022.13.02.013


AMA (American Medical Association) Style

Saif M. Hassan, Raid M Al Abood, Mohammed Jasim Jawad, Mahmood J. Jawad, Nagham Al-Zubidi. DMF Attenuates Ciprofloxacin-Induced Nephropathy in Rats via Nrf2 Pathway. PNR. 2022; 13(2): 87-91. doi:10.47750/pnr.2022.13.02.013



Vancouver/ICMJE Style

Saif M. Hassan, Raid M Al Abood, Mohammed Jasim Jawad, Mahmood J. Jawad, Nagham Al-Zubidi. DMF Attenuates Ciprofloxacin-Induced Nephropathy in Rats via Nrf2 Pathway. PNR. (2022), [cited August 11, 2022]; 13(2): 87-91. doi:10.47750/pnr.2022.13.02.013



Harvard Style

Saif M. Hassan, Raid M Al Abood, Mohammed Jasim Jawad, Mahmood J. Jawad, Nagham Al-Zubidi (2022) DMF Attenuates Ciprofloxacin-Induced Nephropathy in Rats via Nrf2 Pathway. PNR, 13 (2), 87-91. doi:10.47750/pnr.2022.13.02.013



Turabian Style

Saif M. Hassan, Raid M Al Abood, Mohammed Jasim Jawad, Mahmood J. Jawad, Nagham Al-Zubidi. 2022. DMF Attenuates Ciprofloxacin-Induced Nephropathy in Rats via Nrf2 Pathway. Journal of Pharmaceutical Negative Results, 13 (2), 87-91. doi:10.47750/pnr.2022.13.02.013



Chicago Style

Saif M. Hassan, Raid M Al Abood, Mohammed Jasim Jawad, Mahmood J. Jawad, Nagham Al-Zubidi. "DMF Attenuates Ciprofloxacin-Induced Nephropathy in Rats via Nrf2 Pathway." Journal of Pharmaceutical Negative Results 13 (2022), 87-91. doi:10.47750/pnr.2022.13.02.013



MLA (The Modern Language Association) Style

Saif M. Hassan, Raid M Al Abood, Mohammed Jasim Jawad, Mahmood J. Jawad, Nagham Al-Zubidi. "DMF Attenuates Ciprofloxacin-Induced Nephropathy in Rats via Nrf2 Pathway." Journal of Pharmaceutical Negative Results 13.2 (2022), 87-91. Print. doi:10.47750/pnr.2022.13.02.013



APA (American Psychological Association) Style

Saif M. Hassan, Raid M Al Abood, Mohammed Jasim Jawad, Mahmood J. Jawad, Nagham Al-Zubidi (2022) DMF Attenuates Ciprofloxacin-Induced Nephropathy in Rats via Nrf2 Pathway. Journal of Pharmaceutical Negative Results, 13 (2), 87-91. doi:10.47750/pnr.2022.13.02.013