E-ISSN 2229-7723 | ISSN 0976-9234
 

Original Article 


In vitro Quality Assessment and Antibacterial Efficacy of Ciprofloxacin Tablets from Different Pharmaceutical Companies in Community Pharmacies in Iraq

Fatima Alzubaidi, Rafal Jalil Al-Saigh, Enass Oubaid, Charis Liapi, Hussam Al-humadi.

Abstract
Background: Bioequivalence and bioavailability of antimicrobial drugs are considered as a critical issue in treatment of infectious diseases. Recently, some variations have been detected in clinical response to some antimicrobial agents. Ciprofloxacin is one of broad spectrum bactericidal agent that has been used widely in community which motivate us to assess its quality and quantity within available brands. Methods: Ciprofloxacin tablets from brand company (A) and other generic companies (B, C and D) have been selected, a standard powder in specific amount was dissolved and injected directly into HPLC to interpolate with the quantity of ciprofloxacin from each company tablet. In vitro dissolution rate was evaluated for all by calculating the difference and similarity factors. Antimicrobial effect was evaluated by minimum inhibitory concentration (MIC) method for reference strains of low to high level quinolone resistant bacteria. Results: Ciprofloxacin content was approved within accepted range for all companies except D that exceed the rang value. The dissolution testing was very rapid for A and B (>85%) within 15 minutes, while for D was <80% during first 30 minutes. MIC for 24 hours of 0.128-500mg/L ciprofloxacin for all strains showed better results seen in A and B than D. Conclusion: ciprofloxacin tablet of A, B and C companies were approved under the light of the quality test and antibacterial efficacy in comparison with D company, that urge for continuous monitoring and evaluation to avoid drug usefulness and resistance.

Key words: Quality Assessment, Antibacterial Activity, Ciprofloxacin, Dissolution Rate, MIC, Quality Control


 
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How to Cite this Article
Pubmed Style

Alzubaidi F, Al-Saigh RJ, Oubaid E, Liapi C, Al-humadi H, . In vitro Quality Assessment and Antibacterial Efficacy of Ciprofloxacin Tablets from Different Pharmaceutical Companies in Community Pharmacies in Iraq. PNR. 2022; 13(2): 113-118. doi:10.47750/pnr.2022.13.02.018


Web Style

Alzubaidi F, Al-Saigh RJ, Oubaid E, Liapi C, Al-humadi H, . In vitro Quality Assessment and Antibacterial Efficacy of Ciprofloxacin Tablets from Different Pharmaceutical Companies in Community Pharmacies in Iraq. https://www.pnrjournal.com/?mno=99658 [Access: August 11, 2022]. doi:10.47750/pnr.2022.13.02.018


AMA (American Medical Association) Style

Alzubaidi F, Al-Saigh RJ, Oubaid E, Liapi C, Al-humadi H, . In vitro Quality Assessment and Antibacterial Efficacy of Ciprofloxacin Tablets from Different Pharmaceutical Companies in Community Pharmacies in Iraq. PNR. 2022; 13(2): 113-118. doi:10.47750/pnr.2022.13.02.018



Vancouver/ICMJE Style

Alzubaidi F, Al-Saigh RJ, Oubaid E, Liapi C, Al-humadi H, . In vitro Quality Assessment and Antibacterial Efficacy of Ciprofloxacin Tablets from Different Pharmaceutical Companies in Community Pharmacies in Iraq. PNR. (2022), [cited August 11, 2022]; 13(2): 113-118. doi:10.47750/pnr.2022.13.02.018



Harvard Style

Alzubaidi, F., Al-Saigh, R. J., Oubaid, E., Liapi, C., Al-humadi, H. & (2022) In vitro Quality Assessment and Antibacterial Efficacy of Ciprofloxacin Tablets from Different Pharmaceutical Companies in Community Pharmacies in Iraq. PNR, 13 (2), 113-118. doi:10.47750/pnr.2022.13.02.018



Turabian Style

Alzubaidi, Fatima, Rafal Jalil Al-Saigh, Enass Oubaid, Charis Liapi, Hussam Al-humadi, and . 2022. In vitro Quality Assessment and Antibacterial Efficacy of Ciprofloxacin Tablets from Different Pharmaceutical Companies in Community Pharmacies in Iraq. Journal of Pharmaceutical Negative Results, 13 (2), 113-118. doi:10.47750/pnr.2022.13.02.018



Chicago Style

Alzubaidi, Fatima, Rafal Jalil Al-Saigh, Enass Oubaid, Charis Liapi, Hussam Al-humadi, and . "In vitro Quality Assessment and Antibacterial Efficacy of Ciprofloxacin Tablets from Different Pharmaceutical Companies in Community Pharmacies in Iraq." Journal of Pharmaceutical Negative Results 13 (2022), 113-118. doi:10.47750/pnr.2022.13.02.018



MLA (The Modern Language Association) Style

Alzubaidi, Fatima, Rafal Jalil Al-Saigh, Enass Oubaid, Charis Liapi, Hussam Al-humadi, and . "In vitro Quality Assessment and Antibacterial Efficacy of Ciprofloxacin Tablets from Different Pharmaceutical Companies in Community Pharmacies in Iraq." Journal of Pharmaceutical Negative Results 13.2 (2022), 113-118. Print. doi:10.47750/pnr.2022.13.02.018



APA (American Psychological Association) Style

Alzubaidi, F., Al-Saigh, R. J., Oubaid, E., Liapi, C., Al-humadi, H. & (2022) In vitro Quality Assessment and Antibacterial Efficacy of Ciprofloxacin Tablets from Different Pharmaceutical Companies in Community Pharmacies in Iraq. Journal of Pharmaceutical Negative Results, 13 (2), 113-118. doi:10.47750/pnr.2022.13.02.018