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Journal of Pharmaceutical Negative Results
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Year : 2010  |  Volume : 1  |  Issue : 1  |  Page : 24-26

Negative regulation of glucose uptake by Costus pictus in L6 myotube cell line

1 Department of Pharmaceutical Biotechnology, J.S.S. College of Pharmacy, Ootacamund - 643 001, Tamil Nadu, India
2 The Himalaya Drug Company, Makali, Bangalore - 560 123, India
3 Department of Pharmaceutical Science, L. M. College of Science & Technology (Pharmacy Wing), Jodhpur - 342 003, Rajasthan, India

Correspondence Address:
Anil Pareek
Department of Pharmaceutical Science, L. M. College of Science & Technology, Jodhpur-342 003, Rajasthan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-9234.68872

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The leaf of Costus pictus D. Don is considered as an antidiabetic in folklore medicine and is known to reduce the blood sugar, similar to insulin. The aim of this study is to investigate the effect of ethanolic extract of C. pictus leaf on glucose uptake by L6 myotube cell line (skeletal muscle cells) involved in glucose utilization. Ethanolic extract of C. pictus leaf was analyzed to study GLUT4 translocation and glucose uptake activity, but it has no direct peripheral action at 300 μg/ml dose comparable with insulin and metformin. The glucose uptake was not enhanced by the extract of C. pictus leaf.

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