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Journal of Pharmaceutical Negative Results
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Year : 2010  |  Volume : 1  |  Issue : 2  |  Page : 51-54

Absence of central activity in Wrightia tinctoria bark ethanolic extract

1 Radharaman Group of Institutes, Radharaman College of Pharmacy, Fatahpur Dopra, Ratibad, Bhopal, MP, India
2 Rayat College of Pharmacy, Rail Majra, near Ropar Nawanshahr, Punjab, India

Correspondence Address:
P Bigoniya
Principal, Radharaman College of Pharmacy, Radharaman Group of Institutes, Bhadbada Road, Ratibad, Bhopal, MP
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-9234.75705

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Objective: The objective of the present study was to investigate the central activity profile of Wrightia tinctoria (Roxb) R.Br. Linn. (Family: Apocynaceae) in mice and rats using various models. Materials and Methods: The effects of ethanolic extract were observed in 3 different dose levels 300, 500, and 1000 mg/kg as the extract did not show any signs of toxicity up to 5000 mg/kg (p.o.) dose. Investigations were carried out for assessing the activity on pentobarbitone-induced hypnosis and maximum electro-shock (MES)- and leptazole-induced convulsions. Results: W. tinctoria ethanolic extract did not have any significant effect on pentobarbitone-induced hypnosis. The extract is devoid of any protective effect against leptazole- or MES-induced convulsions at any of the tested doses. Conclusion: W. tinctoria bark ethanolic extract had no central nervous system depressant or anticonvulsant activity.

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