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ORIGINAL ARTICLE
Year : 2011  |  Volume : 2  |  Issue : 1  |  Page : 14-19

Negative intercepts in the Heckel analysis of the crude extract of Vernonia galamensis: A major setback of the equation


Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria

Correspondence Address:
Musa Autamashih
Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-9234.82987

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Introduction: The dry powdered leaf of Vernonia galamensis (Asteraceae) has been used by traditional herbalists in northern Nigeria to treat diabetes mellitus. However, medicinal plants used in folk medicine have no standard dose or acceptable method of formulation. In this study therefore, the leaves of Vernonia galamensis (Asteraceae) were extracted, evaluated for pharmacological activity and formulated into tablets. Materials and Methods: The extract was found to be highly hygroscopic and deliquescent, therefore the following efflorescent diluents; aerosil® 200 (GmbH, Meggle, Germany), avicel PH 101 (Honey Well and Stein, UK), and anhydrous calcium phosphate (BDH chemicals, England) were used. The wet granulation method was employed for the tablet formulation and the compaction characteristics of the granules were determined using the Heckel equation. Results and Conclusions: Negative intercepts were a setback to the use of the Heckel equation due to the resulting negative values of D A and D B . This makes it difficult to explain the compaction characteristics of the crude extract.


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