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Journal of Pharmaceutical Negative Results
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Year : 2011  |  Volume : 2  |  Issue : 1  |  Page : 8-13

Effect of grinding on in vitro floating behaviour of effervescent matrix tablets of ciprofloxacin hydrochloride: Negative impact on initial buoyancy

1 Department of Pharmaceutical Sciences, Sardar Bhagwan Singh PG Institute of Biomedical Sciences and Research, Balawala, Dehradun, India
2 Department of Pharmaceutical Sciences, Guru Ram Das Institute of Management and Technology, Dehradun, India
3 Product Development and Research (Formulation and Development), Jubilant Life Sciences, Noida, India

Correspondence Address:
Jeetendra Singh Negi
Department of Pharmaceutical sciences, Sardar Bhagwan Singh PG Institute of Biomedical Sciences and Research, Balawala, Uttarakhand Technical University, Dehradun - 248 161
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-9234.82984

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The purpose of this study was to form dispersion of sodium bicarbonate in hydroxyl-propyl methyl cellulose (HPMC K4M) matrix and investigate its impact on in vitro floating behaviour and drug release. The dispersion of sodium bicarbonate in HPMC K4M was achieved by grinding method using mortar and pestle. The in vitro floating behaviour and drug release of matrix tablets having grinding dispersion (GD) were compared with matrix tablets having physical mixture. The GD matrix tablets were having higher values of buoyancy lag time (BLT) in comparison to PM matrix tablets. However, the floating duration of GD matrix tablets was higher than that for PM matrix tablets. The swelling extent was also found higher for GD matrix tablets. Higher drug release rate was achieved with GD matrix tablets and drug release kinetics was explained by korsemeyer-peppas model. The values of diffusion coefficient (n) were found between 0.45−0.89, which indicates the anomalous type of drug transport.

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