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Journal of Pharmaceutical Negative Results
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ORIGINAL ARTICLE
Year : 2011  |  Volume : 2  |  Issue : 2  |  Page : 69-72

Effort toward the single pot synthesis of 6-(Biphenyl-4-yl)-2-[2-(indol-1-yl)ethyl]-4,5-dihydropyridazin-3(2H)-one from 6-(Biphenyl-4-yl)-2-[2-(indol-1-yl)ethyl]-4,5-dihydropyridazin-3(2H)-one


1 Department of Pharmacy, GRD (P.G) Institute of Management and Technology, Rajpur, Dehradun;Uttrakhand Technical University, Dehardun, Uttarkhand, India
2 Devsthali Vidyapeeth, College of Pharmacy, Rudrapur, India
3 Department of Pharmacy, GRD (P.G) Institute of Management and Technology, Rajpur, Dehradun, India

Correspondence Address:
Mohammad Asif
Department of Pharmacy, GRD (PG) Institute of Management and Technology, 214-Rajpur Road, Dehradun, Uttarkhand - 248 009
India
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Source of Support: GRD (PG) Institute of Management and Technology, Dehradun, India and to SAIF, CDRI, Lucknow, India, Conflict of Interest: None


DOI: 10.4103/0976-9234.90215

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Background: Many synthetic heterocyclic compounds are known to have different biological activities. Pyridazine and its derivatives are the important six membered heterocyclic compounds containing two N-hetero atoms. The pyridazine moiety is an important structural feature of many biologically active compounds. Pyridazine derivatives show diverse pharmacological properties. Aims and Objectives of the Study: The goal of this study, Pyridazine hold considerable interest relative to the preparation of organic intermediates and physiologically active compounds also. On the basis of its important in reported literature, we synthesized the 6-(Biphenyl-4-yl)-2-[2-(indol-1-yl)ethyl]-4,5-dihydropyridazin-3(2H)-one from 6-(Biphenyl-4-yl)-2-[2-(indol-1-yl)ethyl]-4,5-dihydro pyridazin-3(2H)-one in single step or pot reaction. Results : The important Observations and concrete implications of the study. The result showed that the compound 6-(Biphenyl-4-yl)-2-[2-(indol-1-yl) ethyl]-4,5-dihydropyridazin-3(2H)-one was not prepared by this method. The synthesis of compound has been confirmed by the spectral analysis namely IR, 1H NMR and Mass spectroscopy.


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