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Journal of Pharmaceutical Negative Results
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Year : 2011  |  Volume : 2  |  Issue : 2  |  Page : 91-98

A comparative study of pheniramine and lorazepam for physiological and cognitive/psychomotor task impairment

1 Department of Psychiatry and De-addiction, Lady Hardinge Medical College and SSK Hospital, New Delhi, India
2 National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Yatan Pal Singh Balhara
Department of Psychiatry and De-addiction, Lady Hardinge Medical College and SSK Hospital, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-9234.90221

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Context: Pheniramine is being used harmfully in combination with opiates and benzodiazepines through injecting route. Aims: The present study is an attempt to compare the physiological and psychomotor/cognitive task performance on pheniramine and lorazepam. Settings and Design: The study used a double blind randomly allotted cross-over design. Materials and Methods: The doses of the drugs used were placebo (normal saline) - 2 ml, Pheniramine maleate - 45.5 mg, Lorazepam - 2 mg. The assessments were made at base line and then at 15 min., 120 min and 240 min. The subjects were assessed for the socio-demographic profile, drug use history, physiological parameters (pulse rate, BP, respiratory rate), and psychomotor/cognitive tasks. Statistical Analysis used : Analysis was carried out using SPSS ver 10.0. In between, drug comparisons were done using one-way ANOVA (multiple comparisons). Results: Physiological and cognitive/psychomotor tasks performance did not show any significant difference between pheniramine, lorazepam and placebo. Conclusions: The findings suggest the pheniramine and lorazepam have comparable impairment on physiological and cognitive/psychomotor task performance.

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