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Journal of Pharmaceutical Negative Results
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Year : 2012  |  Volume : 3  |  Issue : 1  |  Page : 26-28

Lack of diuretic activity of hot water extract of whole plant of Amaranthus viridis L. in rats

1 Department of Zoology, University of Colombo, Nugegoda, Sri Lanka
2 Department of Zoology University of Sri Jayawardenapura, Nugegoda, Sri Lanka
3 Department of Zoology Nidhana Chikitsa, Institute of Indigenous Medicine, University of Colombo, Rajagiriya, Sri Lanka

Correspondence Address:
W D Ratnasooriya
Department of Zoology, University of Colombo, Colombo 03
Sri Lanka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-9234.99646

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Objective: To assess the diuretic potential of hot water extract (HWE) of a whole plant of Amaranthus viridis L. Materials and Methods: Different doses (25, 50, and 100 mg / kg) of HWE of the whole plant of A. viridis or vehicle or furosemide, reference drug, was orally administered to hydrated rats (n = six / group) and their cumulative urine output was monitored at hourly intervals for five hours. Result: The HWE of A.viridis does not possess significant (P > 0.05) diuretic activity. Conclusion : The HWE of the whole plant of A. viridis did not possess diuretic activity in rats, as was claimed in traditional and folkloric medicine.

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