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Journal of Pharmaceutical Negative Results
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Year : 2012  |  Volume : 3  |  Issue : 1  |  Page : 46-48

No evidence of antiprotozoal property of asteracid weeds Sphaeranthus indicus Linn

Department of Zoology, Moolji Jaitha College, Jalgaon, Maharashtra, India

Correspondence Address:
Namrata V Nemade
Department of Zoology, Moolji Jaitha College, Jalgaon - 425 002, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-9234.99666

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Introduction: Sphaeranthus indicus Linn, an asteracid weed, has been studied by various researchers. The flower of S. indicus possesses biological activities like Nematicidal, Larvicidal, Piscicidal and others, for example, agricultural. Objective: The present investigation for the antiprotozoal activitiy of a methanolic extract (MeOHx) and the alkaloidal fraction (SAF) of the flowers of Sphaeranthus indicus Linn. has been undertaken. Materials and Methods: The study was carried out in seven groups of the Paramecium sp. by using the hemocytometer technique. Different concentrations of MeOHx (50 and 100 μg / ml) and SAF (20 and 40 μg / ml) were applied. The percent mortality was calculated and the results were expressed by using the probit analysis. Results: There was no significant activity against the tested protozoa. Conclusion: Thus, the results of the present investigation suggest that MeOHx and SAF are not responsible for the antiprotozoal property of S. indicus.

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