Advertisment ACS-IndiaSymposium
 
Journal of Pharmaceutical Negative Results
  Print this page Email this page Small font sizeDefault font sizeIncrease font size 
Search Article 
  
Advanced search 
 Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts  
 
ORIGINAL ARTICLE
Year : 2013  |  Volume : 4  |  Issue : 1  |  Page : 54-59

Chronic use of 17β-Ethinyl estradiol on cardiovascular hemodynamic profile: "Friend or foe"?


1 Department of Pharmacology, Subharti Medical College, Meerut, India
2 Department of Pharmacology, Kharvel Subharti College of Pharmacy, Meerut, India
3 Department of Pharmacology, LLRM Medical College, Meerut, India
4 Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India

Correspondence Address:
Hira Lal Bhalla
Department of Pharmacology, Subharti Medical College, Subharti Puram Delhi-Haridwar By-Pass Road, Meerut - 250 005, Uttar Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-9234.116761

Rights and Permissions

Introduction: The effects of ovariectomy (Ovx), menopause, and estrogen replacement on the hemodynamic remain controversial. This study employed the technique of impedance cardiography analysis to measure the effect of chronic use of estrogen replacement on cardiovascular hemodynamic in the Ovx rats. Materials and Methods: Colony-bred adult Ovx female Sprague-Dawley rats were randomized into three groups: 17 β-Ethinyl Estradiol treated ovariectomized group (OvxE), vehicle treated ovariectomized group (OvxV), and Sham Operated (SO). Animals received 17 β-Ethinyl Estradiol (17 β-EE) once daily for 90 days. Cardiovascular hemodynamic parameters such as left ventricular ejection time (LVET), pre-ejection period (PEP), Systolic time interval (STI), cardiac output (CO), cardiac index (CI), stroke volume (SV), and stroke volume index (SVI) were assessed 24 h after last treatment on 7, 15, 30, 60, or 90 days. Results: Compared to SO group, Ovx with or without estrogen replacement did not significantly affect the mean blood pressure, CO, CI, SV, and SVI. No significant changes were observed in LVET and PEP from SO. Treatment with estradiol increased the STI by 66.62% and 53.60% ( P < 0.05), from control after 60 and 90 days, respectively. Blood velocity, base impedance (Zo) and maximum change in impedance during systole (Zt) corresponding to time-varying fluid volume (blood) remained within normal limits of variation. Conclusion: These results demonstrate that on long-term administration of estrogen significantly increased STI in rats.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2898    
    Printed113    
    Emailed0    
    PDF Downloaded253    
    Comments [Add]    

Recommend this journal