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Journal of Pharmaceutical Negative Results
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ORIGINAL ARTICLE
Year : 2014  |  Volume : 5  |  Issue : 1  |  Page : 19-21

Lack of diuretic activity of water extract of leaves of Pongamia pinnata L. in rats


1 Department of Chemistry, Animal House, University of Colombo, Colombo 08, Sri Lanka
2 Department of Zoology, Animal House, University of Colombo, Colombo 08, Sri Lanka
3 Department of Medical Faculty, Animal House, University of Colombo, Colombo 08, Sri Lanka

Correspondence Address:
S A Deraniyagala
Department of Chemistry, University of Colombo, Colombo 03
Sri Lanka
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Source of Support: A Grant of S. A. Deraniyagala from University of Colombo (AP/3/2/00/05) is greatly acknowledged., Conflict of Interest: None


DOI: 10.4103/0976-9234.136782

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Objective : To assess the diuretic potential of water extract (WE) of leaves of Pongamia pinnata L. Materials and Methods : Different doses (500, 1000, 1500, and 3000 mg/kg) of WE of the leaves of P. pinnata or vehicle or furosemide, reference drug was orally administered to hydrated rats (n = 6/group) and their cumulative urine output was monitored at hourly intervals for 6 h. Result : The WE of P. pinnata does not possess significant (P > 0.05) diuretic activity. Conclusion : The WE of the leaves of P. pinnata did not possess diuretic activity in rats as was claimed in traditional and folkloric medicine.


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