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Journal of Pharmaceutical Negative Results
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Year : 2014  |  Volume : 5  |  Issue : 1  |  Page : 39-44

Long-term ethanol diet (based on waste powder as vehicle) does not cause liver injury in C57BL/6 and A/J mice

Laboratório de Virologia Molecular, Instituto Carlos Chagas (ICC-FIOCRUZ/PR), Curitiba, Paraná, Brazil

Correspondence Address:
Lorena Bavia
Instituto Carlos Chagas, Fundacao Oswaldo Cruz, Rua Prof. Algacyr Munhoz Mader, 3775 - CIC, Curitiba, CEP: 81350 010, Parana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-9234.136795

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Background: Alcohol abuse is increasing worldwide in the human population and causes severe damage such as steatosis, hepatitis, and cirrhosis. Alcoholic individuals recurrently are more susceptible to infectious diseases since alcohol metabolites affect the innate and acquired immune responses. Hence, there is a need for animal models to study alcohol-induced pathologies. Materials and Methods: In order to establish an alternative and cheaper protocol to perform mice alcohol feeding, powder from regular chow CR-1 was mixture with water and agar generating a semi-solid vehicle-diet in which ethanol was added. As pair-fed control glucose was equicalorically added to the semi-solid vehicle-diet. Results: Four weeks later, both ethanol and glucose diets did not cause hematological, physiological and pathological changes in C57BL/6 and A/J mice. Conclusions: Our results contributed to development of a new chow approach as vehicle-diet for substances soluble in ethanol or water. In addition, our results propose an alternative to powder chow destination.

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