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Journal of Pharmaceutical Negative Results
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Year : 2015  |  Volume : 6  |  Issue : 1  |  Page : 11-19

Insignificant antitubercular activity of pyrazoline, phenyl pyrazoline and isoxazoline moiety in lupeol

Department of Pharmaceutical Chemistry, Institute of Pharmacy, Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh, India

Correspondence Address:
Vandana Khattar
Institute of Pharmacy, Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-9234.157379

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Aim: The Present study is to investigate the antimycobacterial activity of pyrazoline, phenyl pyrazoline and isooxazoline moiety containing lupeol. The main purpose to show insignificant antimicrobial activity of these lupeol derivatives and hence that further researchers do not waste time to investigate antitubercular activity of these group containing lupeol derivatives. Materials and Methods: Lupeol has been isolated from Crataeva nurvala and its reported antitubercular activity prompted to prepare semisynthetic derivatives to know how much they show antitubercular activity. Newer substituted derivatives of lupeol were synthesized by firstly oxidation of lupeol to lupeol aldehyde followed by replacement of aldehydic group by various groups as pyrazoline, phenyl pyrazoline and Isooxazoline. These Pyrozoline, Phenyl pyrazoline and Isooxazoline derivatives are synthetic analogues of the naturally occurring triterpenoid lupeol from the plant crataeva nurvala, were tested for their spectral data and conformation of the groups, then tested these derivatives of lupeol for antitubercular activity against Mycobacterium tuberculosis (MTB) strain H37Rv using the Microplate Alamar Blue Assay. Result: The result indicate that pyrazoline, Phenyl pyrazoline and Isooxazoline moiety containing lupeol derivatives did not show antimycobacterial activity against MTB at 50 μgm/ml. Conclusion: Pyrazoline, Phenyl pyrazoline and Isooxazoline derivative of lupeol did not have significant antimycobacterial activity. Thus, further optimization of it is needed.

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