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Journal of Pharmaceutical Negative Results
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Year : 2016  |  Volume : 7  |  Issue : 1  |  Page : 21-24

Lack of anthelmintic activity of Kalanchoe pinnata fresh leaves

Directorate of Research, Krishna Institute of Medical Sciences, Deemed University, Karad, Maharashtra, India

Correspondence Address:
Rohan Sharadanand Phatak
Directorate of Research, Krishna Institute of Medical Sciences Deemed University, NH-4, Near Dhebewadi Road, Malkapur, Karad - 415 539, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-9234.177056

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Objective: The main objective was to explore the anthelmintic capacity of Kalanchoe pinnata (K. pinnata). Materials and Methods: Petroleum ether and methanolic extracts of K. pinnata were extracted by maceration methods. Both the extracts were investigated for their anthelmintic activity against Pheretima posthuma. Different concentrations of 25 mg/mL, 50 mg/mL, 100 mg/mL, and 200 mg/mL of both extracts were studied by determining time of paralysis (PT) and time of death (DT) of the earthworms. Results: Both the extracts have exhibited no anthelmintic activity even at the highest concentration of 200 mg/mL. A concentration of 15 mg/mL of albendazole was used as standard reference or positive control while normal saline was used as negative control. Conclusion: This study has revealed that in vitro anthelmintic activity of K. pinnata leaves lacks anthelmintic property. Both the extracts of this plant have displayed no vermicide activity against the earthworms used in the study.

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