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Journal of Pharmaceutical Negative Results
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Year : 2016  |  Volume : 7  |  Issue : 1  |  Page : 29-32

Insignificant effect of ethanol extract of Dipterocarpus turbinatus (Dipterocarpaceae) bark on selected parameter in alloxan-induced diabetic rats

1 Department of Pharmacognosy, Creative Educational Society's College of Pharmacy, Kurnool, Andhra Pradesh, India
2 Department of Pharmacology, NET College of Pharmacy, Raichur, Karnataka, India
3 Department of Pharmacognosy, Prime College of Pharmacy, Palakkad, Kerala, India

Correspondence Address:
Diptanu Biswas
Department of Pharmacognosy, Creative Educational Society's College Pharmacy, NH-7, Chinnatekur, Kurnool - 518 218, Andhra Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-9234.177059

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Objective: The present investigation was designed to find out the antidiabetic potency of ethanol extract of the bark of Dipterocarpus turbinatus by alloxan monohydrate-induced diabetic rats. Materials and Methods: The bark powder of D. turbinatus was extracted with different solvents (according to the polarity of the solvent). Preliminary phytochemical evaluation of the plants showed different chemical entities including alkaloids, steroids, flavonoids, terpenoids, and tannins. Ethanol extracts (200 mg/kg and 400 mg/kg body weight) were used for antidiabetic study. Oral administration of ethanol extract of the stem bark of D. turbinatus in alloxan monohydrate (150 mg/kg) induces diabetic rats for 14 days. Results and Discussion: Various parameters such as blood glucose level, body weight, and various biochemical parameters (plasma cholesterol, serum creatinine, and urea) were measured by the spectrophotometric method. There was no significant reduction seen in the blood glucose as compared with the diabetic control from the 200 mg/kg dose (P < 0005), and no positive effect could be shown on biochemical parameters as compared with the diabetic control group in both concentrations (200 mg/kg and 400 mg/kg). Conclusion: On the basis of this investigation, we may partially conclude that D. turbinatus is not a potent antidiabetic agent.

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