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LETTER TO THE EDITOR
Year : 2017  |  Volume : 8  |  Issue : 1  |  Page : 56-57  

Underreporting of mild adverse events during plateletpheresis donations


Department of Transfusion Medicine, Gian Sagar Medical College and Hospital, Patiala, Punjab, India

Date of Web Publication21-Apr-2017

Correspondence Address:
Sonam Kansay
Department of Transfusion Medicine, Gian Sagar Medical College and Hospital, Patiala, Punjab
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-9234.204911

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How to cite this article:
Kansay S. Underreporting of mild adverse events during plateletpheresis donations. J Pharm Negative Results 2017;8:56-7

How to cite this URL:
Kansay S. Underreporting of mild adverse events during plateletpheresis donations. J Pharm Negative Results [serial online] 2017 [cited 2017 Sep 23];8:56-7. Available from: http://www.pnrjournal.com/text.asp?2017/8/1/56/204911

Dear Sir,

Data are lacking on the incidence of adverse effects of donations made with modern apheresis instruments.[1] Hence, we analyzed a total of 90 plateletpheresis procedures over a period of 3 months (September 2015 to November 2015) on Trima Accel cell separator. Donors were selected as per the set criteria for single donor platelet preparation according to the AABB guidelines. All the 90 donors were male with mean age 30.5 years and mean weight 77.3 kg [Table 1]. Of these 90 donors, 23 donors (25.6%) developed some adverse events (AE) [Table 2].
Table 1: Plateletpheresis donor details

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Table 2: Type and severity of adverse events among plateletpheresis donors

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Similar to Philip et al. study, no severe adverse reactions were observed, but the overall rate of AE was very high in this study (25.6%) as compared to other studies from the literature.[2] About 65.2% of AE were due to mild citrate toxicity. It is very important to elicit the presence of the early and mild symptoms from the donor so that interventions can occur before the more severe symptoms develop. Neglecting the mild AE not only results in underreporting of these events but also negative donor experience which can further result in poor donor return and it could be a possible reason for poor plateletpheresis donor inventories worldwide. Since citrate reactions are the most common and are inevitable; so strategies to prevent or minimize them further need to be evaluated. Moreover, constant supervision by an expert physician and nursing staff cannot only detect the AE at the earliest, but prompt intervention and proper donor counseling can improve the overall outcome. About 34.8% of AE were vascular complications which could be significantly reduced by recruiting trained and professional phlebotomists. Obtaining data on the incidence of AE enables the dynamic review of the medical and nursing teams to improve safety and comfort for the donor.[3] Hence, it is recommended to discuss and create a system of hemovigilance for AE in donations with special consideration to mild AE which are usually underreported.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Crocco I, Franchini M, Garozzo G, Gandini AR, Gandini G, Bonomo P, et al. Adverse reactions in blood and apheresis donors: Experience from two Italian transfusion centres. Blood Transfus 2009;;7:35-8.  Back to cited text no. 1
    
2.
Philip J, Sarkar RS, Pathak A, Adverse events associated with apheresis procedures: Incidence and relative frequency. Asian J Transfus Sci 2013;;7:37-41.  Back to cited text no. 2
    
3.
Barbosa MH, da Silva KF, Coelho DQ, Tavares JL, da Cruz LF, Kanda MH, Risk factors associated with the occurrence of adverse events in plateletpheresis donation. Rev Bras Hematol Hemoter 2014;;36:191-5.  Back to cited text no. 3
    



 
 
    Tables

  [Table 1], [Table 2]



 

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