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Year : 2018  |  Volume : 9  |  Issue : 1  |  Page : 14-20

Tetrandrine beads using alginate/polyvinyl alcohol and alginate-carboxymethyl cellulose: Not ideal as colon-targeted dosage form

Department of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia

Correspondence Address:
Raditya Iswandana
Faculty of Pharmacy, Universitas Indonesia, Depok 16424
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jpnr.JPNR_25_17

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Objectives: Colon drug delivery system should be able to maintain drug release until the system reaches its target. In this study, beads were selected as drug carrier system to deliver tetrandrine to colon using a combination of two polymers, alginate and polyvinyl alcohol (PVA) and also alginate and carboxymethyl cellulose (CMC). It was hypothesized that alginate/PVA beads and alginate-CMC beads may be able to protect the drug effectively while in the gastrointestinal tract and may deliver the drug at colon under the influence of colonic pH. Materials and Methods: Beads were formulated into six formulae with different concentrations of polymer. Beads were characterized and evaluated for in vitro drug release using dissolution method. Results: Beads' Formula 3 (alginate and PVA 2:1) and Formula 6 (alginate and CMC 2:1.5) were the best formulae with entrapment efficiency 32.12% and 39.83%, respectively. The drug release test was performed first in hydrochloric acid (HCl) medium for 2 h, then in phosphate-buffered pH 7.4 + 2% Tween 80 for 3 h, and finally in phosphate-buffered pH 6.8 + 2% Tween 80 medium for 3 h, successively. The results of drug release in HCl pH 1.2 were 84.13%, 73.12%, 66.57%, 85.59%, 78.26%, and 69.56%, for Formula 1, 2, 3, 4, 5, and 6, respectively. Conclusion: All type of beads showed the high release of tetrandrine in HCl; hence, it is not ideal yet as a colon-targeted dosage form.

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