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Journal of Pharmaceutical Negative Results
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Year : 2018  |  Volume : 9  |  Issue : 1  |  Page : 21-26

Evaluation of the activity of Tontelea micrantha extracts against bacteria, Candida and Mayaro virus

1 Federal University of São João del-Rei – Campus Centro-Oeste Dona Lindu, MG, Brazil
2 Department of Biological Sciences, Federal University of Ouro Preto, MG, Brazil
3 Department of Chemistry, Biotechnology and Bioprocess Engineering, Federal University of São João del-Rei – Campus Alto Paraopeba, MG, Brazil
4 Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, MG, Brazil
5 Department of Pharmacy, Federal University of Ouro Preto, MG, Brazil

Correspondence Address:
José Carlos De Magalhães
Rodovia Mg 443, Km 7, Federal University of São João del-Rei, Campus Alto Paraopeba, Ouro Branco, MG
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jpnr.JPNR_8_18

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Objectives: This work aimed to evaluate the antibacterial, antifungal, and anti-Mayaro virus(MAYV) activity of leaf and branch extracts from Tontelea micrantha. Materials and Methods: T. micrantha extracts were prepared through the partition of the leaf and branch samples in different solvents. Then, the antibacterial and antifungal activity was assessed against bacterial pathogens and Candida sp. by the determination of the minimum inhibitory concentration (MIC) by the broth microdilution method. The activity against anti-MAYV was evaluated through the quantification of the extract concentration that promoted the protection of 50% of the cells after the viral infection. Results: The extracts of T. micrantha were inactive (MIC >500 μg/mL) against Gram-positive, Gram-negative and Candida species at the highest concentration tested (500 μg/mL). Anti-MAYV activity was also not detected, with SI <10, ranging from 1.2 to 3.6. Conclusion: Although it is used in traditional medicine, Leaf and branch extracts from T. micrantha did not present antimicrobial activity, which could be caused by the antagonistic effect of the compounds present in the extract.

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