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ORIGINAL ARTICLE
Year : 2018  |  Volume : 9  |  Issue : 1  |  Page : 39-43

Triazole-chalcones: Lack of antibacterial, anti-candida, and anti-dengue virus activities


1 Laboratory of Medical Microbiology, Central-West Campus Dona Lindu, Federal University of São João del-Rei, Divinopolis, MG, Brazil
2 Department of Bioprocess Engineering, Laboratory of Molecular and Cellular Biology, Alto Paraopeba Campus, Federal University of São João del-Rei, Ouro Branco, MG, Brazil
3 Laboratory of Molecular Biology, Central-West Campus Dona Lindu, Federal University of São João del-Rei, Divinopolis, MG, Brazil
4 Laboratory of Organic Synthesis and Nanostructures, Central-West Campus Dona Lindu, Federal University of São João del-Rei, Divinopolis, MG, Brazil
5 Laboratory of Pharmaceutical Chemistry, Central-West Campus Dona Lindu, Federal University of São João del-Rei, Divinopolis, MG, Brazil
6 Milwaukee Area Technical College, Milwaukee, WI, USA

Correspondence Address:
Jaqueline Maria Siqueira Ferreira
Laboratory of Medical Microbiology, Central-West Campus Dona Lindu, Federal University of São João del-Rei. 400 Sebastiao Gonçalves Coelho Street, Chanadour, Divinopolis, MG
Brazil
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jpnr.JPNR_2_18

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Background: The need to identify new antimicrobial drugs that present different mechanisms of action is urgent. The variety of biological properties of chalcones give them a potential therapeutic compounds. Chalcones' synthetic manipulations are investigated worldwide in search of more powerful and efficient drugs to several infectious diseases' treatment. Objective: The purpose of this work was to evaluate the potential antibacterial, antifungal, and anti-dengue virus (DENV) of new ten triazole chalcones. Materials and Methods: Triazole chalcones were used to determine its antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), Gram-negative bacteria (Klebsiella pneumoniae, Enterobacter cloacae, Acinetobacter baumannii, and Pseudomonas aeruginosa) species, and anti-Candida activity (Candida albicans) by the broth microdilution assay. The anti-DENV activity was evaluated by cell viability quantification after viral infection by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay. Results: Although Triazole chalcones have shown a low cytotoxicity concentration (with CC50of 47.21–192.51 μg/mL), these compounds did not exhibit antimicrobial activity against Gram-negative and Gram-positive bacteria, C. albicans neither DENV, even in the highest concentration tested. Triazole chalcones had no activity against all tested microorganisms, except for Gram-positive S. epidermidis bacteria when a poor antimicrobial effect was observed (125 μg/mL). Conclusion: The results suggest that triazole chalcones investigated in this study are not promising antimicrobial agents.


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