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Journal of Pharmaceutical Negative Results
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ORIGINAL ARTICLE
Year : 2019  |  Volume : 10  |  Issue : 1  |  Page : 47-51

Effects of Vitamin D3 supplementation on the hematological indices in women presented with iron deficiency anemia: An open-labeled clinical trial


1 Department of Clinical Pharmacology and Therapeutics, College of Pharmacy, Hawler Medical University, Erbil; Department of Clinical Pharmacology and Therapeutics, School of Medicine, Faculty of Medical Sciences, University of Sulaimani, Sulaimani, Iraq
2 Department of Pharmacology, School of Medicine, Faculty of Medical Sciences, University of Sulaimani, Sulaimani, Iraq

Correspondence Address:
Marwan S. M Al-Nimer
Department of Clinical Pharmacology and Therapeutics, College of Pharmacy, Hawler Medical University, Erbil; Department of Clinical Pharmacology and Therapeutics, School of Medicine, Faculty of Medical Sciences, University of Sulaimani, Sulaimani
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jpnr.JPNR_7_19

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Objectives: Vitamin D inhibits erythropoiesis in healthy, young individuals, despite its positive effect on the absorption of iron. This study aimed to investigate the effects of Vitamin D supplements as add-on therapy on the hematological indices of adults presented with iron deficiency anemia (IDA). Materials and Methods: Eighty-two women aged 20–45 years with IDA were recruited from Shar Teaching Hospital and the Center of Blood Diseases in Sulaimani city, North Iraq. The patients were grouped into Group I (n = 35) treated with elemental iron and Group II (n = 47) treated with elemental iron plus Vitamin D3 supplements (oral dose of 300,000 IU every 2 weeks), for 8 weeks. Hematological indices and the serum ferritin were determined before the treatment and after 8 weeks of treatment. Results: Vitamin D3 supplements significantly elevate the total white cell count and decreased platelet indices values. It decreased the platelet-to-lymphocyte ratio significantly from 123.24 ± 32.00 to 107.68 ± 30.06, P < 0.001. The serum ferritin level did not normalize after 8 weeks of treatment with elemental iron and Vitamin D3 supplements. Conclusions: Vitamin D3 supplement as the add-on therapy is less effective in IDA, and it impacts negatively against the blood platelet indices.


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