Advertisment ACS-IndiaSymposium
 
Journal of Pharmaceutical Negative Results
  Print this page Email this page Small font sizeDefault font sizeIncrease font size 
Search Article 
  
Advanced search 
 Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts  
 
ORIGINAL ARTICLE
Year : 2020  |  Volume : 11  |  Issue : 1  |  Page : 42-46

Evaluation of anticancer potential of Eleusine indica methanolic leaf extract through Ras- and Wnt-related pathways using transgenic Caenorhabditis elegans strains


1 Department of Medical Technology, Caenorhabditis elegans Research Group, Institute of Arts and Sciences, Far Eastern University; Department of Biology, College of Arts and Sciences, University of the Philippines, Manila, Philippines
2 Department of Medical Technology, Caenorhabditis elegans Research Group, Institute of Arts and Sciences, Far Eastern University, Manila, Philippines

Correspondence Address:
Prof. John Sylvester B Nas
Department of Biology, University of the Philippines, Manila
Philippines
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jpnr.JPNR_7_20

Rights and Permissions

Background: In the Philippines, many accounts have resurfaced claiming different herbal and therapeutic advantages of Eleusine indica. One of these advantages is its anticancer potential. Despite some studies showing that the crude extract has cytotoxic and radical scavenging activity, it is still insufficient and further scientific evidence is needed to support this claim. Aim: Hence, we evaluate the anticancer potential of E. indic a methanolic leaf extract (EMLE) by focusing on two cancer-related pathways, Ras and Wnt pathways. Subjects and Methods: We used wild-type and transgenic Caenorhabditis elegans strains which have an irregular Ras or Wnt signaling. We determined the average number of eggs laid of each strain and the multivulva development of the Ras-mutant strain. Results: Our experiments show that EMLE does not affect the number of eggs laid of the wild-type, Ras-mutant-and Wnt-mutant worms. Furthermore, EMLE was not able to reduce Ras-mutant population demonstrating multi-vulva. Conclusion: Taken together, our data suggest that the anticancer potential of EMLE may be independent of Ras and Wnt signaling pathways.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed101    
    Printed5    
    Emailed0    
    PDF Downloaded14    
    Comments [Add]    

Recommend this journal