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ORIGINAL ARTICLE
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Larvicidal activity of chemically synthesized silver nanoparticles against anopheles stephensi


1 Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences; Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran
3 Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences; Medical Biomaterials Research Center, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Amir Amani,
Department of Medical Nanotechnology, Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran
Iran
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jpnr.JPNR_18_17

   Abstract 


Background: Silver nanoparticles (AgNPs) have wide applications in different fields such as medicine, food industry, and pest management. Larvicidal activity of many herbally biosynthesized AgNPs have been evaluated against main malaria vector, that is, Anopheles stephensi. However, results of the studies are very different. No report has been found on larvicidal activity of chemically synthesized AgNPs against A. stephensi. Materials and Methods: AgNPs were synthesized using chemical reduction and characterized by dynamic light scattering and transmission electron microscopy. Concentration of silver ion in the final solution was determined by ICP-AES. Turbidity of solutions of AgNPs at different concentrations (i.e., 0.2–100 ppm) was studied. Subsequently, larvicidal activity of nanoparticles was evaluated, in line with the WHO guideline for laboratory tests. Results: AgNPs were synthesized successfully and confirmed by ultraviolet analysis. Nanoparticles were spherical with a diameter of ~30 nm. AgNPs had no larvicidal activity up to 80 ppm and showed a small larvicidal effect (~20%) at 100 ppm. Conclusion: Chemically synthesized AgNPs are not proper candidates for control of larvae due to their low efficacy and effects on nontarget specious lived in stagnant water.

Keywords: Chemical reduction, larvicidal activity and Anopheles stephensi, silver nanoparticles, silver nitrate, sodium borohydride



How to cite this URL:
Osanloo M, Amini SM, Sedaghat MM, Amani A. Larvicidal activity of chemically synthesized silver nanoparticles against anopheles stephensi. J Pharm Negative Results [Epub ahead of print] [cited 2019 Jan 21]. Available from: http://www.pnrjournal.com/preprintarticle.asp?id=239961

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