Journal of Pharmaceutical Negative Results

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 1  |  Issue : 2  |  Page : 58--60

Insignificant antidiabetic activity of rhizome of Zingiber zerumbet


VK Lal1, A Pandey2, P Tripathi2, RD Pandey2 
1 Sagar Institute of Technology and Management, Barabanki, India
2 Institute of Technology and Management, Gorakhpur, India

Correspondence Address:
A Pandey
Institute of Technology & Management, AL-1 Sector-7, GIDA, Gorakhpur 273 209, Uttar Pradesh
India

Objective: To investigate the antidiabetic activity of Z. zerumbet in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: The diabetic rats were given aqueous extract of Z. zerumbet (200 mg/kg) and glibenclamide (10 mg/kg) for 21 days, and their hypoglycemic activity and effect on body weight were assessed. Result: The treatment with aqueous extract of Z. zerumbet and glibenclamide both showed hypoglycemic activity but efficacy of Z. zerumbet is not as significant as glibenclamide. Glibenclamide maintain the body weight of rats throughout the study period, whereas the body weight of Z. zerumbet-treated rats significantly falls. Conclusion: This study suggests that aqueous extract of Z. zerumbet shows no significant activity in STZ-induced diabetic rats.


How to cite this article:
Lal V K, Pandey A, Tripathi P, Pandey R D. Insignificant antidiabetic activity of rhizome of Zingiber zerumbet.J Pharm Negative Results 2010;1:58-60


How to cite this URL:
Lal V K, Pandey A, Tripathi P, Pandey R D. Insignificant antidiabetic activity of rhizome of Zingiber zerumbet. J Pharm Negative Results [serial online] 2010 [cited 2019 Oct 17 ];1:58-60
Available from: http://www.pnrjournal.com/article.asp?issn=0976-9234;year=2010;volume=1;issue=2;spage=58;epage=60;aulast=Lal;type=0