Journal of Pharmaceutical Negative Results

LETTER TO EDITOR
Year
: 2011  |  Volume : 2  |  Issue : 1  |  Page : 43--44

Animal research: reporting in vivo experiments: New guideline for reporting animal research


Jaykaran 
 Department of Pharmacology, Govt. Medical College, Surat, India

Correspondence Address:
Jaykaran
Department of Pharmacology, Govt. Medical College, Surat
India




How to cite this article:
Jaykaran. Animal research: reporting in vivo experiments: New guideline for reporting animal research.J Pharm Negative Results 2011;2:43-44


How to cite this URL:
Jaykaran. Animal research: reporting in vivo experiments: New guideline for reporting animal research. J Pharm Negative Results [serial online] 2011 [cited 2020 Sep 20 ];2:43-44
Available from: http://www.pnrjournal.com/text.asp?2011/2/1/43/82980


Full Text

Sir,

It is been observed that articles published in various biomedical journals report insufficient information related to various components of study, many studies done for the articles published in western journals prove it. [1] Few studies done for Indian medical journals also supported the above facts. [2] Because of this insufficient information, not only the value of study gets decreased but also doing critical analysis of study becomes difficult. When a study is done, various resources are used including time, money and skills and when sufficient information is not given in the article, it leads to wastage of these resources as because of insufficient information study become unusable. Lots of affords are done for the proper reporting of research and many guidelines are formulated for the same. One of the popular guideline is CONSORT (consolidated standard of reporting of trial) statement for reporting of randomized trials. [3] Instruction of author section of majority of journals mentions about the use of this guideline. [4] It has been observed that quality of reporting of trials get improved after the CONSORT statement comes into existence. [5] But it was also an important issue that though many such guidelines were formulated for clinical research, animal studies were seemed to be overlooked. Animal studies like human studies are also not devoid of problem of insufficient and selective information given in the article, though this issue is not explored much as it is explored for clinical research. In a survey supported by "The National Centre for the Replacement, Refinement and Reduction of Animals in Research" and done by Kilkenni et al, on 271 animal studies published in USA and UK, it was found that many components were missing in the articles which can provide important information regarding the quality of study. [6] In this survey, it was observed that randomization, blinding and full information related to statistics and sample size calculation were missing in most of the animal studies. [6] In a small survey done by us for articles (84% of them were animal studies) published in an Indian journal in 2007-2008, we observed sufficient information related to sample size calculation, statistics (like assumptions of statistical tests, confidence interval) were lacking. [7] Hence, there was a need of guideline like CONSORT statement of trials for animal studies so that there can be a better reporting of parameters of animal studies. This need seems to be fulfilled by new guideline given for reporting of animal studies. It is called ARRIVE (animals in research: reporting in vivo experiments) guideline. [8] This guideline is supported by the National Centre for the Replacement, Refinement and Reduction of Animals in Research and is based on CONSORT statement. This guideline is formulated with the consultation of various scientists, statisticians, research funders and editors of some high impact journals like Nature Cell biology, British Journal of Pharmacology, Science etc. This guideline is a 20-point checklist explaining various components required to be reported in the article like title, abstract, background, objective, ethical statement, study design, experimental procedure, experimental animals, housing and husbandry, sample size, allocation of animals to experimental group, experimental outcomes, statistical methods, baseline data, numbers analyzed, outcomes and estimation, adverse events, interpretation, generalizability and funding. According to the authors, this guideline is neither mandatory nor is an attempt to standardize the reporting of animal studies. [8] But it can serve as a guideline to authors during writing the manuscript and for peer reviewers during analyzing the articles.

References

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2Karan J, Kantharia ND, Yadav P, Bhardwaj P. Reporting statistics in clinical trials published in Indian journals: A survey. Pak J Med Sci 2010;26:212-6.
3Moher D, Schulz KF, Altman DG; the CONSORT Group. The CONSORT statement: Revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet 2001;357:1191-4.
4Altman DG. Endorsement of the CONSORT statement by high impact medical journals: Survey of instructions for authors. BMJ 2005;330:1056-7.
5Plint AC, Moher D, Morrison A, Schulz K, Altman DG, Hill C, et al. Does the CONSORT checklist improve the quality of reports of randomised controlled trials? A systematic review. Med J Aust 2006;185:263-7.
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