Journal of Pharmaceutical Negative Results

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 2  |  Issue : 2  |  Page : 91--98

A comparative study of pheniramine and lorazepam for physiological and cognitive/psychomotor task impairment


Yatan Pal Singh Balhara1, Raka Jain2, Anju Dhawan2, Manju Mehta2 
1 Department of Psychiatry and De-addiction, Lady Hardinge Medical College and SSK Hospital, New Delhi, India
2 National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Yatan Pal Singh Balhara
Department of Psychiatry and De-addiction, Lady Hardinge Medical College and SSK Hospital, New Delhi
India

Context: Pheniramine is being used harmfully in combination with opiates and benzodiazepines through injecting route. Aims: The present study is an attempt to compare the physiological and psychomotor/cognitive task performance on pheniramine and lorazepam. Settings and Design: The study used a double blind randomly allotted cross-over design. Materials and Methods: The doses of the drugs used were placebo (normal saline) - 2 ml, Pheniramine maleate - 45.5 mg, Lorazepam - 2 mg. The assessments were made at base line and then at 15 min., 120 min and 240 min. The subjects were assessed for the socio-demographic profile, drug use history, physiological parameters (pulse rate, BP, respiratory rate), and psychomotor/cognitive tasks. Statistical Analysis used : Analysis was carried out using SPSS ver 10.0. In between, drug comparisons were done using one-way ANOVA (multiple comparisons). Results: Physiological and cognitive/psychomotor tasks performance did not show any significant difference between pheniramine, lorazepam and placebo. Conclusions: The findings suggest the pheniramine and lorazepam have comparable impairment on physiological and cognitive/psychomotor task performance.


How to cite this article:
Balhara YS, Jain R, Dhawan A, Mehta M. A comparative study of pheniramine and lorazepam for physiological and cognitive/psychomotor task impairment.J Pharm Negative Results 2011;2:91-98


How to cite this URL:
Balhara YS, Jain R, Dhawan A, Mehta M. A comparative study of pheniramine and lorazepam for physiological and cognitive/psychomotor task impairment. J Pharm Negative Results [serial online] 2011 [cited 2020 Jul 9 ];2:91-98
Available from: http://www.pnrjournal.com/article.asp?issn=0976-9234;year=2011;volume=2;issue=2;spage=91;epage=98;aulast=Balhara;type=0