Journal of Pharmaceutical Negative Results

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 6  |  Issue : 1  |  Page : 27--32

Insignificant activity of extracts of Gmelina asiatica and Ipomoea digitata against skin pathogens


Chandrika Mahendra1, D Vishakante Gowda2, U Venkata Babu1 
1 Research and Development, The Himalaya Drug Company, Makali, Bangalore, India
2 Department of Pharmaceutics, JSS College of Pharmacy, Mysore, Karnataka, India

Correspondence Address:
Chandrika Mahendra
The Himalaya Drug Company, Makali, Tumkur Road, Bangalore - 562 162, Karnataka
India

Objective: To study the antimicrobial activity of Gmelina asiatica aerial parts and Ipomoea digitata tubers against organisms causing acne, dandruff, and body malodor. Materials and Methods: The plant materials were extracted with petroleum ether, chloroform, ethyl acetate, and methanol using Soxhlet extraction unit. The extracts were tested for antimicrobial activity against Malassezia furfur, Propionibacterium acnes, and Corynebacterium diphtheriae at 1 mg/mL, 20 mg/mL, and 50 mg/mL concentrations, respectively. Results: The chloroform and ethyl acetate extracts of I. digitata showed mild antibacterial activity against C. diphtheriae at 20 mg/mL and 50 mg/mL concentration levels (13-14 mm), respectively and did not show any activity against P. acnes. The petroleum ether extract exhibited a zone of inhibition against C. diphtheriae at 50 mg/mL. The petroleum ether, chloroform, and ethyl acetate extracts of G. asiatica showed zones of inhibition in the range 12-13 mm, and of P. acnes and C. diphtheria, at 50 mg/mL. None of the extracts showed activity against M. furfur. The methanol extracts of both the plants failed to show any activity against all the selected organisms. Conclusion: The study showed that the plant extracts exhibit weak antimicrobial activity at the levels tested. Therefore, the extracts evaluated in this study cannot be used as alternatives to existing antimicrobial agents for acne, dandruff, and body malodor.


How to cite this article:
Mahendra C, Gowda D V, Babu U V. Insignificant activity of extracts of Gmelina asiatica and Ipomoea digitata against skin pathogens.J Pharm Negative Results 2015;6:27-32


How to cite this URL:
Mahendra C, Gowda D V, Babu U V. Insignificant activity of extracts of Gmelina asiatica and Ipomoea digitata against skin pathogens. J Pharm Negative Results [serial online] 2015 [cited 2019 Oct 21 ];6:27-32
Available from: http://www.pnrjournal.com/article.asp?issn=0976-9234;year=2015;volume=6;issue=1;spage=27;epage=32;aulast=Mahendra;type=0