Journal of Pharmaceutical Negative Results

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 8  |  Issue : 1  |  Page : 43--48

The evaluation of quercetin and luteolin efficacy on cutaneous leishmaniasis in mice infected with Leishmania major


Nasrin Hamidizadeh1, Sara Ranjbar1, Qasem Asgari2, Gholamreza Hatam3 
1 Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2 Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3 Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz; Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Correspondence Address:
Gholamreza Hatam
Basic Sciences in Infectious Diseases Research Center, School of medicine, Shiraz University of Medical Sciences, Shiraz
Iran

Introduction: Almost 1.5-2 million people are infected with leishmaniasis and 60,000 die due to the disease every year. The treatment of cutaneous leishmaniasis with the existing medications is not effective and accompanied with various side effects. Expensiveness and not being available in different forms are other limitations associated with these drugs. In addition to, parasite resistance restricts the use of these medications; therefore, identification of new treatment methods is highly essential. Humans have always used medicinal plants for the treatment of diseases. This study aimed to assess the impact of quercetin and luteolin on leishmaniasis wounds created on mice's tails. Materials and Methods: A total of 56 infected Balb/C mice were divided into eight groups, each containing seven animals. The first three groups received 3.5 mg/kg luteolin through oral, intradermal, and intraperitoneal routes. The other three groups received 14 mg/kg quercetin through oral, intradermal, and intraperitoneal routes. The treatments were administered twice a week for 4 weeks in comparison to meglumine antimonite as control groups. Results: The results showed that there was no statistically significant difference between the recovery of mice in the luteolin and quercetin groups and those in the meglumine antimonite group. However, the ratio of recovered Balb/C mice in the luteolin and quercetin group is 1.75-2 times more than meglumine group, respectively. Conclusion: Quercetin and luteolin seems to be candidate medications with fewer side effects for recovery from cutaneous leishmaniasis. They can also be used as complementary medications together with other standard drugs, such as meglumine, antimonite, and cryotherapy.


How to cite this article:
Hamidizadeh N, Ranjbar S, Asgari Q, Hatam G. The evaluation of quercetin and luteolin efficacy on cutaneous leishmaniasis in mice infected with Leishmania major.J Pharm Negative Results 2017;8:43-48


How to cite this URL:
Hamidizadeh N, Ranjbar S, Asgari Q, Hatam G. The evaluation of quercetin and luteolin efficacy on cutaneous leishmaniasis in mice infected with Leishmania major. J Pharm Negative Results [serial online] 2017 [cited 2019 Dec 16 ];8:43-48
Available from: http://www.pnrjournal.com/article.asp?issn=0976-9234;year=2017;volume=8;issue=1;spage=43;epage=48;aulast=Hamidizadeh;type=0