Journal of Pharmaceutical Negative Results

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 9  |  Issue : 1  |  Page : 39--43

Triazole-chalcones: Lack of antibacterial, anti-candida, and anti-dengue virus activities


Michelli dos Santos1, Felipe Rocha Da Silva Santos1, Ariane Coelho Ferraz2, Jéssica Tauany Andrade1, Karina Marjorie Silva Herrera1, William Gustavo Lima1, Lailah Horácio Sales Pereira3, Marina Goulart da Silva4, José Augusto Ferreira Perez Villar4, José Carlos de Magalhães2, Alex Gutterres Taranto5, Luciana Lara dos Santos3, Jamária Adriana Pinheiro Soares-Martins6, Jaqueline Maria Siqueira Ferreira1 
1 Laboratory of Medical Microbiology, Central-West Campus Dona Lindu, Federal University of São João del-Rei, Divinopolis, MG, Brazil
2 Department of Bioprocess Engineering, Laboratory of Molecular and Cellular Biology, Alto Paraopeba Campus, Federal University of São João del-Rei, Ouro Branco, MG, Brazil
3 Laboratory of Molecular Biology, Central-West Campus Dona Lindu, Federal University of São João del-Rei, Divinopolis, MG, Brazil
4 Laboratory of Organic Synthesis and Nanostructures, Central-West Campus Dona Lindu, Federal University of São João del-Rei, Divinopolis, MG, Brazil
5 Laboratory of Pharmaceutical Chemistry, Central-West Campus Dona Lindu, Federal University of São João del-Rei, Divinopolis, MG, Brazil
6 Milwaukee Area Technical College, Milwaukee, WI, USA

Correspondence Address:
Jaqueline Maria Siqueira Ferreira
Laboratory of Medical Microbiology, Central-West Campus Dona Lindu, Federal University of São João del-Rei. 400 Sebastiao Gonçalves Coelho Street, Chanadour, Divinopolis, MG
Brazil

Background: The need to identify new antimicrobial drugs that present different mechanisms of action is urgent. The variety of biological properties of chalcones give them a potential therapeutic compounds. Chalcones' synthetic manipulations are investigated worldwide in search of more powerful and efficient drugs to several infectious diseases' treatment. Objective: The purpose of this work was to evaluate the potential antibacterial, antifungal, and anti-dengue virus (DENV) of new ten triazole chalcones. Materials and Methods: Triazole chalcones were used to determine its antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), Gram-negative bacteria (Klebsiella pneumoniae, Enterobacter cloacae, Acinetobacter baumannii, and Pseudomonas aeruginosa) species, and anti-Candida activity (Candida albicans) by the broth microdilution assay. The anti-DENV activity was evaluated by cell viability quantification after viral infection by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay. Results: Although Triazole chalcones have shown a low cytotoxicity concentration (with CC50of 47.21–192.51 μg/mL), these compounds did not exhibit antimicrobial activity against Gram-negative and Gram-positive bacteria, C. albicans neither DENV, even in the highest concentration tested. Triazole chalcones had no activity against all tested microorganisms, except for Gram-positive S. epidermidis bacteria when a poor antimicrobial effect was observed (125 μg/mL). Conclusion: The results suggest that triazole chalcones investigated in this study are not promising antimicrobial agents.


How to cite this article:
Santos Md, Da Silva Santos FR, Ferraz AC, Andrade JT, Silva Herrera KM, Lima WG, Sales Pereira LH, da Silva MG, Perez Villar JA, de Magalhães JC, Taranto AG, dos Santos LL, Pinheiro Soares-Martins JA, Siqueira Ferreira JM. Triazole-chalcones: Lack of antibacterial, anti-candida, and anti-dengue virus activities.J Pharm Negative Results 2018;9:39-43


How to cite this URL:
Santos Md, Da Silva Santos FR, Ferraz AC, Andrade JT, Silva Herrera KM, Lima WG, Sales Pereira LH, da Silva MG, Perez Villar JA, de Magalhães JC, Taranto AG, dos Santos LL, Pinheiro Soares-Martins JA, Siqueira Ferreira JM. Triazole-chalcones: Lack of antibacterial, anti-candida, and anti-dengue virus activities. J Pharm Negative Results [serial online] 2018 [cited 2019 Sep 19 ];9:39-43
Available from: http://www.pnrjournal.com/article.asp?issn=0976-9234;year=2018;volume=9;issue=1;spage=39;epage=43;aulast=Santos;type=0