Journal of Pharmaceutical Negative Results

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 10  |  Issue : 1  |  Page : 47--51

Effects of Vitamin D3 supplementation on the hematological indices in women presented with iron deficiency anemia: An open-labeled clinical trial


Marwan S. M Al-Nimer1, Raz M HamaSalih2 
1 Department of Clinical Pharmacology and Therapeutics, College of Pharmacy, Hawler Medical University, Erbil; Department of Clinical Pharmacology and Therapeutics, School of Medicine, Faculty of Medical Sciences, University of Sulaimani, Sulaimani, Iraq
2 Department of Pharmacology, School of Medicine, Faculty of Medical Sciences, University of Sulaimani, Sulaimani, Iraq

Correspondence Address:
Marwan S. M Al-Nimer
Department of Clinical Pharmacology and Therapeutics, College of Pharmacy, Hawler Medical University, Erbil; Department of Clinical Pharmacology and Therapeutics, School of Medicine, Faculty of Medical Sciences, University of Sulaimani, Sulaimani
Iraq

Objectives: Vitamin D inhibits erythropoiesis in healthy, young individuals, despite its positive effect on the absorption of iron. This study aimed to investigate the effects of Vitamin D supplements as add-on therapy on the hematological indices of adults presented with iron deficiency anemia (IDA). Materials and Methods: Eighty-two women aged 20–45 years with IDA were recruited from Shar Teaching Hospital and the Center of Blood Diseases in Sulaimani city, North Iraq. The patients were grouped into Group I (n = 35) treated with elemental iron and Group II (n = 47) treated with elemental iron plus Vitamin D3 supplements (oral dose of 300,000 IU every 2 weeks), for 8 weeks. Hematological indices and the serum ferritin were determined before the treatment and after 8 weeks of treatment. Results: Vitamin D3 supplements significantly elevate the total white cell count and decreased platelet indices values. It decreased the platelet-to-lymphocyte ratio significantly from 123.24 ± 32.00 to 107.68 ± 30.06, P < 0.001. The serum ferritin level did not normalize after 8 weeks of treatment with elemental iron and Vitamin D3 supplements. Conclusions: Vitamin D3 supplement as the add-on therapy is less effective in IDA, and it impacts negatively against the blood platelet indices.


How to cite this article:
Al-Nimer MS, HamaSalih RM. Effects of Vitamin D3 supplementation on the hematological indices in women presented with iron deficiency anemia: An open-labeled clinical trial.J Pharm Negative Results 2019;10:47-51


How to cite this URL:
Al-Nimer MS, HamaSalih RM. Effects of Vitamin D3 supplementation on the hematological indices in women presented with iron deficiency anemia: An open-labeled clinical trial. J Pharm Negative Results [serial online] 2019 [cited 2020 Feb 17 ];10:47-51
Available from: http://www.pnrjournal.com/article.asp?issn=0976-9234;year=2019;volume=10;issue=1;spage=47;epage=51;aulast=Al-Nimer;type=0