Journal of Pharmaceutical Negative Results

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 10  |  Issue : 1  |  Page : 57--62

Comparing the efficacy of dexmedetomidine, dexamethasone, and metoclopramide in postoperative nausea and vomiting of tympanomastoidectomy surgery: A double-blind randomized clinical trial


Hesameddin Modir1, Esmail Moshiri1, Alireza Kamali1, Atefeh Khalifeh2, Abolfazl Mohammadbeigi3 
1 Department of Anesthesiology and Critical Care, Arak University of Medical Sciences, Arak, Iran
2 Department of Student Research Committee, Arak University of Medical Sciences, Arak, Iran
3 Research Center for Environmental Pollutants, Qom University of Medical Sciences, Qom, Iran

Correspondence Address:
Esmail Moshiri
Department of Anesthesiology and Critical Care, Arak University of Medical Sciences, Arak
Iran

Objective: Postoperative nausea and vomiting (PONV) are of the most common complications after anesthesia and surgery that affects 20%–30% of patients. This study aimed to examine the efficacy of dexmedetomidine (DEXM), dexamethasone (DEXA), and metoclopramide (METO) on the reduction of PONV after tympanomastoidectomy. Materials and Methods: In a clinical trial study, 90 patients who undergoing tympanomastoidectomy surgery were assigned to DEXM (1 μg/kg/intravenous [IV]), DEXA (0.1 mg/kg/IV), and METO (0.15 mg/kg/IV) groups by block randomization method. The initial vital signs and vomiting score as responses to treatment were assessed using visual analog scale through 24 h (6, 12, 18, and 24) after the end of surgery. The vomiting score varied from 0 (no vomiting) to 100 (the worst possible vomiting). One-way analysis of variance (ANOVA), paired t-test, and repeated measure ANOVA was used for statistical analysis in SPSS version 12.5 (SPSS Inc., Chicago, IL, USA). Results: The incidence of PONV was 10%, in DEXM 0%, DEXA 6.7%, and 23.3% in METO. Vomiting score is much lower for the DEXM than for the other two groups, and rather rapidly declined 18 h after the intervention. The difference of time 6–24 was significant among three groups (P < 0.05). A greater reduction observed in vomiting total scores in DEXM group compared to other groups at time 18–24 as well as time 6–24. Conclusion: DEXM, DEXA, and METO are effective drugs for control of PONV after tympanomastoidectomy surgery. However, the reduction effect of DEXM and DEXA in vomiting total scores was higher than METO.


How to cite this article:
Modir H, Moshiri E, Kamali A, Khalifeh A, Mohammadbeigi A. Comparing the efficacy of dexmedetomidine, dexamethasone, and metoclopramide in postoperative nausea and vomiting of tympanomastoidectomy surgery: A double-blind randomized clinical trial.J Pharm Negative Results 2019;10:57-62


How to cite this URL:
Modir H, Moshiri E, Kamali A, Khalifeh A, Mohammadbeigi A. Comparing the efficacy of dexmedetomidine, dexamethasone, and metoclopramide in postoperative nausea and vomiting of tympanomastoidectomy surgery: A double-blind randomized clinical trial. J Pharm Negative Results [serial online] 2019 [cited 2020 Feb 17 ];10:57-62
Available from: http://www.pnrjournal.com/article.asp?issn=0976-9234;year=2019;volume=10;issue=1;spage=57;epage=62;aulast=Modir;type=0