Journal of Pharmaceutical Negative Results

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 11  |  Issue : 1  |  Page : 1--8

No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis


Thara Tunthanathip1, Kantapong Mamueang2, Nichapat Nilbupha2, Chattarin Maliwan2, Tanan Bejrananda3 
1 Department of Surgery, Division of Neurosurgery, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
2 Department of Medical Education, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
3 Department of Surgery, Division of Urology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand

Correspondence Address:
Dr. Thara Tunthanathip
Department of Surgery, Division of Neurosurgery, Faculty of Medicine, Prince of Songkla University, Songkhla 90110
Thailand

Objective: To systematically examine the prognostic significance of isocitrate dehydrogenase 1 (IDH1) mutations according to country region. Methods: We searched five electronic databases from inception to September 2019 for relevant studies. A meta-analysis was performed after evaluating which studies met the inclusion criteria. Thirty-seven were identified for this meta-analysis, comprising 5141 GBM patients. Results: The benefit of overall survival (OS) was the hazard ratio (HR), 0.67 (95% confidence interval [CI], 0.61–0.74). When subgroup analysis by country region, the pooled HR for the Eastern population studies was 1.15 (95% CI: 0.97–1.35) with no association between IDH1 mutation and OS of GBM, while IDH1 mutation still had a significant survival advantage in the Western population studies (HR: 0.51, 95% CI: 0.45–0.57). Conclusions: This study confirmed that IDH1 mutation is an independent prognostic factor for patients with GBM. However, a topographic relationship was observed in the results, and an association between this genetic mutation and prognosis should be explored in future studies.


How to cite this article:
Tunthanathip T, Mamueang K, Nilbupha N, Maliwan C, Bejrananda T. No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis.J Pharm Negative Results 2020;11:1-8


How to cite this URL:
Tunthanathip T, Mamueang K, Nilbupha N, Maliwan C, Bejrananda T. No association between isocitrate dehydrogenase 1 mutation and increased survival of glioblastoma: A meta-analysis. J Pharm Negative Results [serial online] 2020 [cited 2020 Aug 4 ];11:1-8
Available from: http://www.pnrjournal.com/article.asp?issn=0976-9234;year=2020;volume=11;issue=1;spage=1;epage=8;aulast=Tunthanathip;type=0