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Journal of Pharmaceutical Negative Results
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  Citation statistics : Table of Contents
   2010| July-September  | Volume 1 | Issue 1  
    Online since September 20, 2010

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No evidence of antiseptic properties and low toxicity of selected Aloe species
L Mpala, G Chikowe, IE Cock
July-September 2010, 1(1):10-16
Background and Aim: Closely related plant species often share similar secondary metabolites and bioactivities and are therefore good targets for bioactivity testing when one or more species within a genus are known to possess therapeutic properties. The genus Aloe has a long history of medicinal usage in many areas of the world. Many species are known to have therapeutic properties, several species of which have well-established antibacterial bioactivities. The current studies examine the toxicity of several Aloe species and their ability to inhibit bacterial growth and compare them to the most extensively studied species, Aloe barbadensis, which has well-established antibacterial bioactivities. Results: A. barbadensis methanolic extract displayed broad spectrum antibacterial activity, inhibiting the growth of 8 of the 14 bacteria tested (57%). It was effective against both Gram-positive and Gram-negative bacteria, inhibiting the growth of 4 of 4 Gram-positive bacteria (100%) and 4 of 10 Gram-negative (40%) bacteria tested, respectively. In contrast, Aloe elgonica, Aloe pruinosa, Aloe chabaudii, Aloe daiyana, Aloe marlothi and Aloe vryheidensis all showed no antibacterial activity toward any of the bacteria tested. All of the Aloe species displayed low toxicity similar to that of the A. barbadensis control. A. daiyana was the most toxic of the Aloe species tested with 24, 48 and 72 hours LC50 values of 1018.2, 517.0 and 405.7 ΅g/ml, respectively. Conclusions: Despite their close taxonomic relationship, A. elgonica, A. pruinosa, A. chabaudii, A. daiyana, A. marlothi and A. vryheidensis do not have the same antibacterial medicinal potential as A. barbadensis, but may still have other similar toxicity-related bioactivities. Testing against protozoa, fungi, virus and tumor cells is required to determine if this is the case.
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Negative regulation of glucose uptake by Costus pictus in L6 myotube cell line
Anil Pareek, Manish Suthar, Ashok Godavarthi, Manoj Goyal, Vijay Bansal
July-September 2010, 1(1):24-26
The leaf of Costus pictus D. Don is considered as an antidiabetic in folklore medicine and is known to reduce the blood sugar, similar to insulin. The aim of this study is to investigate the effect of ethanolic extract of C. pictus leaf on glucose uptake by L6 myotube cell line (skeletal muscle cells) involved in glucose utilization. Ethanolic extract of C. pictus leaf was analyzed to study GLUT4 translocation and glucose uptake activity, but it has no direct peripheral action at 300 μg/ml dose comparable with insulin and metformin. The glucose uptake was not enhanced by the extract of C. pictus leaf.
  4 10,365 964
Negative results as part of quality research: An insight
Javed Ali
July-September 2010, 1(1):4-5
  2 2,819 610
Uncovering negative results: Introducing an open access journal "Journal of Pharmaceutical Negative Results"
Vipra Kundoor, KK Mueen Ahmed
July-September 2010, 1(1):1-3
  1 2,851 614
Do medicinal plants possess significant activities?
Sanjib Bhattacharya, KK Mueen Ahmed, Vipra Kundoor
July-September 2010, 1(1):27-28
  1 2,909 725
Failure to detect the anti-mutagenic effect of insulin in experimental type-2 diabetic rats
Syed Imam Rabbani, Kshama Devi, Salma Khanam
July-September 2010, 1(1):17-21
Background: The oxidative stress is known to cause mutation-related disorders in diabetic patients. Materials and Methods: The present study was designed to investigate the anti-mutagenic effect of insulin in nicotinamide (NA: 230 mg/kg, i.p.) and streptozotocin (STZ: 65 mg/kg, i.p.) induced nuclear defects. Bone marrow micronucleus (MN) test and caudal epididymal sperm abnormalities were detected to find the somatic and germinal cell mutations, respectively. The antioxidant status was determined by estimating serum lipid peroxidation, catalase, superoxide dismutase and glutathione peroxidase levels. Results: The experimental type diabetes significantly (P < 0.001) reduced the antioxidant status and enhanced MN frequency and sperm defects compared to control animals. Although administration of insulin (1, 3, 5 and 7 IU/kg, s.c. for 4 weeks) significantly (P < 0.001) reduced hyperglycemia, it did not alter the antioxidant status, and somatic and germinal cell defects in diabetic rats. Conclusion: The results suggest that insulin did not have protective effect against the genotoxicity induced by NA-STZ diabetes.
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Lack of analgesic activity of petroleum ether extract of Bauhinia racemosa Lam in rats and mice
KS Chandrashekar, KS Prasanna
July-September 2010, 1(1):22-23
Objective: The effect of petroleum ether extract of Bauhinia racemosa was investigated in rats and mice to evaluate the analgesic activity. Materials and Methods: Acetic acid induced writhing model and hot plate method were employed to test the analgesic activity. Results: The results indicated that the petroleum ether extract had no significant analgesic activity. Conclusion: It may be inferred that Bauhinia racemosa do not have analgesic activity and the results are not in agreement with its traditional use.
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Compromising research for publishing thirst: Maladies and remedies
Bhupinder Singh
July-September 2010, 1(1):6-9
In the current scenario of academic-research, the publication process has become much more demanding and intricate. Every academician and principal investigator of a research project is constrained to publish high quality work in high impact journals. This unquenchable thirst of publishing is evident form the exponentially escalating number of journals and papers in the last one decade. The hallmarks of scientific research and publishing, i.e., ethics and integrity, are consequently getting attenuated. The current article is an endeavor to highlight the major unethical compromises which the authors are tempted to make while publishing their research. Accentuating "Good Publishing Practices", the article serves as a ready-reckoner on various Do's and Don'ts for young scientists and academicians to practice.
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