Evaluation Of Silver Nanogel Loaded With Micronised Activated Charcoal For Wound Healing Applications
This study reports experiments that aims to combine silver and activated charcoal in a gel formulation to potentially create a gel that is suitable for use in treating infected wounds and prevent wounds from being infected; Method: Gels that were created were characterised via pH, moisture content, and spreadability analysis. Fourier Transformed Infrared (FTIR) spectrometry was used to check for the functional groups present in the formulation to ensure that the components of the gels were properly incorporated. Stability testing was tested by storing gels in different temperatures and rechecking the physical characteristics. Finally, for its antibacterial activity assessment, staphylococcus aureus ATCC 25923 strain was used to perform antibacterial studies via well diffusion assay and Minimum Bactericidal Concentration (MBC) measurement described by a previous paper. Results: Stability studies showed that all physical properties of the gel generally maintained, while antibacterial effect in disc diffusion testing and minimum bactericidal concentration testing was inconclusive, with one formulation showing a significantly smaller zone of inhibition; Conclusions: The gels made in this experiment seemed to not show antibacterial effect that was consistent, future studies should replace silver nitrate with silver sulfadiazine in formulation and in vivo testing should be considered.