Anti-Parkinsonian Effect Of Momordica Dioica On Haloperidol Induced Parkinsonism In Wistar Rats

Authors

  • Rahaman Shaik , Basavaraju sreevani , K. Ravishanker , T. Naga Aparna , K. Hemanth , Rohit Kumar , Jaffer Sadik

DOI:

https://doi.org/10.47750/pnr.2023.14.03.10

Abstract

In a rat haloperidol model of Parkinson's disease, the current study demonstrates that an ethanolic leaf extract of Momordica dioica has an anti-parkinsonian effect. Testing for the drug's anti-parkinsonism properties involves inducing Parkinsonism in rats with haloperidol. The ethanolic leaves extract of Momordica dioica at a dose of 500 mg/kg, p.o, displayed a stronger pharmacological impact than 250 mg/kg when compared to L-Dopa and Carbidopa (100mg+25mg/kgi.p). Parkinsonism in people or animal models is hypothesized to arise as a result of dopamine deficiency. An increase in dopamine content may have restored the change in locomotor activity and exploratory behavior, similar to the N. Jatamansi treatment. According to earlier research, Momordica dioica extract has strong antioxidant activities and may have provided protection against Parkinson's disease brought on by haloperidol. Numerous researchers have discovered. Numerous studies have found. Numerous investigations have found Numerous investigations have documented increased serotonergic neurotransmission in the CNS as a result of neuroleptic-induced catalepsy. The two primary dopamine pathways in the brain are the nigrostraited route and the mesolimbic pathway.

Additionally, momordica dioica is a rich source of numerous nutrients that are necessary for healthy body operation. It contains 4.1 calories, phytic acid -2.8 mg/g, iron -0.14 mg/g, zinc -1.34 mg/g, sodium -1.5 mg/potassium -8.3 mg/g, calcium -0.5 mg/g, sodium -1.5 mg/potassium -8.3 mg/g, protein -19.38%, fat -4.7%, total phenolic compound 3.7 mg/g, and phytic acid -2.8 mg/g. Momordica dioica has been demonstrated to have anti-feedant, anti-allergic, anti-fertility, analgesic, and anti-inflammatory qualities. It also possesses antidiabetic and hepatoprotective properties.

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Published

2023-01-01 — Updated on 2023-01-01

How to Cite

Rahaman Shaik , Basavaraju sreevani , K. Ravishanker , T. Naga Aparna , K. Hemanth , Rohit Kumar , Jaffer Sadik. (2023). Anti-Parkinsonian Effect Of Momordica Dioica On Haloperidol Induced Parkinsonism In Wistar Rats. Journal of Pharmaceutical Negative Results, 69–81. https://doi.org/10.47750/pnr.2023.14.03.10

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