Comparative Clinical Verification Of Wild And Cultivated R. Serpentina Mother Tincture In Stage I Essential Hypertension

Authors

  • Varsha Umesh Ghate , Manisha P. Gajendragadkar

DOI:

https://doi.org/10.47750/pnr.2023.14.03.12

Abstract

One of the most efficient homoeopathic treatment for hypertension is R. serpentina mother tincture due to presence of indole alkaloid Reserpine. It is overexploited and commonly harvested for commercial purposes which lead to its extinction.   As a result it has now become an endangered plant species in India so manufactures are using cultivated species. Consequently there is a need to scientifically validate comparative clinical verification of wild and cultivated R. serpentina mother tincture in mild essential hypertension. This study was planned for comparative clinical verification of wild and cultivated R. serpentina mother tincture in stage I essential hypertension. Phase II, double blind, randomized, parallel assignment, monocentric, clinical trial was undertaken on the population suffering from Stage I essential hypertension. Out of 503 screened patients, 108 patients were voluntary recruited which fulfill the case definition, inclusion criteria, exclusion criteria. 108 patients suffering from stage I essential hypertension; randomized to receive either wild MT (n = 104) or cultivated MT (n = 104). The therapeutic efficacy of wild and cultivated R. serpentina mother tincture in patients with stage I essential hypertension has been statistically proven. However, effect observed in wild sample are higher than cultivated sample. R. serpentina MT from wild and cultivated species has significantly favorable effect in patients suffering from stage I essential hypertension but R. serpentina MT, from wild species was relatively more effective than those from cultivated ones. To overcome the issue of extinction of Rauvolfia, its cultivation is crucial and further researches must be done to enhance the therapeutic value of cultivated species.

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Published

2023-01-01 — Updated on 2023-01-01

How to Cite

Varsha Umesh Ghate , Manisha P. Gajendragadkar. (2023). Comparative Clinical Verification Of Wild And Cultivated R. Serpentina Mother Tincture In Stage I Essential Hypertension. Journal of Pharmaceutical Negative Results, 89–95. https://doi.org/10.47750/pnr.2023.14.03.12

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