Volatile Alkaloids And Brain Disorder Investigation Of The Cognitive And Mood Effects Of Zingiber Officinale Essential Oil With In Vitro Properties Relevant To Central Nervous System Function

Abstract

As the human life expectancy increases, age-linked diseases have become more and more frequent. The worldwide increment of dementia cases demands medical solutions, but the current available drugs do not meet all the expectations. Recently the attention of the scientific community was attracted by natural compounds, used in ancient medicine, known for their beneficial effects and high tolerability. All these evidences suggest a potential role of the compounds of ginger not only in the treatment of the disease, but also in its prevention.. Ginger (Zingiber officinale Roscoe) is a common and widely used spice. It is rich in various chemical constituents, including phenolic compounds, terpenes, polysaccharides, lipids, organic acids, and raw fibers. The health benefits of ginger are mainly attributed to its phenolic compounds, such as gingerols and shogaols.  This review is focused on Ginger (Zingiber officinale) and explore its properties against Alzheimer Disease and Vascular Dementia, two of the most common and devastating forms of dementia. This work resumes the beneficial effects of Ginger compounds, tested in computational in vitro and in vivo models of Alzheimer’s Disease and Vascular Dementia, along with some human tests.