PRESCRIBING PATTERN OF ANTIMICROBIALS IN PRE AND POST-SURGICAL INFECTIONS IN A TERTIARY CARE HOSPITAL

Abstract

According to the surgical procedure, infections that occur within 30 days following an operation are referred to as surgical site infections (SSI) and may last longer than 30 days. The aim of the study is to evaluate drug use pattern of surgical antimicrobial prophylaxis practice and SSI prevalence among surgically operated patients. The prospective observational study was conducted in tertiary care teaching hospital, Agra. Total number of samples included for this study will be 380 patients using 95% confident interval. During the study period 380 patients underwent various surgeries in the general surgery department in tertiary care hospital, Agra. Among the 380 patients 168 developed mild to moderate surgical site infections giving a cumulative incidence of 44%. The age of study subjects ranged between 31 to 50 years. Cefotaxime was considered as most commonly used antimicrobial prophylaxis it’s more effective. Third generation ceftriaxone was more frequently utilized than first or second generation cephalosporins. Moreover third generation cephalosporins such as ceftriaxone, cefotaxime, ciprofloxacin followed by combination of antimicrobials are particularly effective against the organisms that cause SSI in emergency postoperative patients. This study also indicated that the majority of the antimicrobials used pre and post-surgery were administered through intravenous route.